IMMUNOFLUORESCENT DETECTION O F IgG AT THE DERMAL-EPIDERMAL JUNCTION IN PATIENTS WITH APPARENT PRIMARY FIBROSITIS SYNDROME XAVIER J. CAR0 Primary fibrositis syndrome (PFS) is a common rheumatologic disorder whose etiology remains unknown. It is characterized by complaints of widespread aching, soft tissue tenderness, and a number of associated constitutional symptoms (1,2). By definition, the syndrome is found in the absence of standard laboratory markers for rheumatic disease. This lack of associated laboratory abnormalities has made the identification and study of affected patients difficult. During the course of examining patients with PFS we have frequently observed a reticular skin discoloration (RSD). Since similar skin changes have been seen in association with a number of immunerelated diseases (3), it was postulated that the study of skin from patients with PFS might provide a means of better understanding this disorder. Therefore, 25 patients with apparent PFS were studied for the incidence of RSD and for immunofluorescent evidence of immunoglobulin deposition at the dermal-epidermal junction (DEJ). The results are presented in this report. __ PATIENTS AND METHODS Patients. Twenty-five consecutive patients who apparently satisfied criteria for the diagnosis of PFS were studied. The criteria, suggested by Smythe (1) and modified by Bennett
Arthritis & Rheumatology – Wiley
Published: Oct 1, 1984
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera