IMMUNOFLUORESCENT DETECTION O F IgG AT THE DERMAL-EPIDERMAL JUNCTION IN PATIENTS WITH APPARENT PRIMARY FIBROSITIS SYNDROME XAVIER J. CAR0 Primary fibrositis syndrome (PFS) is a common rheumatologic disorder whose etiology remains unknown. It is characterized by complaints of widespread aching, soft tissue tenderness, and a number of associated constitutional symptoms (1,2). By definition, the syndrome is found in the absence of standard laboratory markers for rheumatic disease. This lack of associated laboratory abnormalities has made the identification and study of affected patients difficult. During the course of examining patients with PFS we have frequently observed a reticular skin discoloration (RSD). Since similar skin changes have been seen in association with a number of immunerelated diseases (3), it was postulated that the study of skin from patients with PFS might provide a means of better understanding this disorder. Therefore, 25 patients with apparent PFS were studied for the incidence of RSD and for immunofluorescent evidence of immunoglobulin deposition at the dermal-epidermal junction (DEJ). The results are presented in this report. __ PATIENTS AND METHODS Patients. Twenty-five consecutive patients who apparently satisfied criteria for the diagnosis of PFS were studied. The criteria, suggested by Smythe (1) and modified by Bennett
Arthritis & Rheumatology – Wiley
Published: Oct 1, 1984
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