Immune deficiency and rosacea

Immune deficiency and rosacea EditorWe thank Ciccarese et al. for their interest in our report.They wonder whether the patients that we reported definitely had demodicidosis associated with rosacea, and above all, they provide their own interesting findings in 60 patients with rosacea, findings that we will not comment here.We agree that skin scraping with a D. folliculorum count is certainly the less unreliable way to support a diagnosis of demodicidosis. We did not perform this test, as in our experience, strong itching in papulopustular rosacea in individuals with immune deficiency is always associated with D. folliculorum proliferation. Furthermore, the key message of our publication was to report the factual occurrence of rosacea segregating with GOF STAT1 mutations in a well‐investigated family, the infection with D. folliculorum being only one possible causative explanation.To respond to their questions, we treated the two individuals (children) who complained about itch. A single dose of ivermectin 200 microgram/kg resulted in almost complete amelioration that lasted about 1–2 months, and treatment was repeated on demand.ReferencesLipsker D, Second J, Korganow AN, Jannier S, Puel A. Rosacea and demodicidosis associated with gain‐of‐function mutation in STAT1. J Eur Acad Dermatol Venereol 2017. https://doi.org/10.1111/jdv.14413.Ciccarese J, Parodi A, Rebora A, Drago AE. The usefulness of investigating the possible underlying conditions in rosacea. J Eur Acad Dermatol Venereol 2017. https://doi.org/10.1111/jdv.14547. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the European Academy of Dermatology & Venereology Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 European Academy of Dermatology and Venereology
ISSN
0926-9959
eISSN
1468-3083
D.O.I.
10.1111/jdv.14544
Publisher site
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Abstract

EditorWe thank Ciccarese et al. for their interest in our report.They wonder whether the patients that we reported definitely had demodicidosis associated with rosacea, and above all, they provide their own interesting findings in 60 patients with rosacea, findings that we will not comment here.We agree that skin scraping with a D. folliculorum count is certainly the less unreliable way to support a diagnosis of demodicidosis. We did not perform this test, as in our experience, strong itching in papulopustular rosacea in individuals with immune deficiency is always associated with D. folliculorum proliferation. Furthermore, the key message of our publication was to report the factual occurrence of rosacea segregating with GOF STAT1 mutations in a well‐investigated family, the infection with D. folliculorum being only one possible causative explanation.To respond to their questions, we treated the two individuals (children) who complained about itch. A single dose of ivermectin 200 microgram/kg resulted in almost complete amelioration that lasted about 1–2 months, and treatment was repeated on demand.ReferencesLipsker D, Second J, Korganow AN, Jannier S, Puel A. Rosacea and demodicidosis associated with gain‐of‐function mutation in STAT1. J Eur Acad Dermatol Venereol 2017. https://doi.org/10.1111/jdv.14413.Ciccarese J, Parodi A, Rebora A, Drago AE. The usefulness of investigating the possible underlying conditions in rosacea. J Eur Acad Dermatol Venereol 2017. https://doi.org/10.1111/jdv.14547.

Journal

Journal of the European Academy of Dermatology & VenereologyWiley

Published: Jan 1, 2018

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