Identity of the soluble ebv‐associated antigens of human lymphoid cell lines

Identity of the soluble ebv‐associated antigens of human lymphoid cell lines The reactions of human sera with antigens prepared from five human lymphoid cell lines were studied by immunodiffusion. Two major precipitation lines occurred with QIMR‐WIL antigens; one (S line) due to a soluble antigen and the other (F line) due to a sedimentable antigen. A close association in human sera of precipitins producing the S line with antibody to Epstein‐Barr virus (EBV) detectable by immunofluorescence (Henle test) and by complement fixation (CF) tests indicated a specific association of the S line with EBV, but the nature of the F line was not clarified. Soluble antigens prepared from five lymphoid cell lines (including Raji) contained at least one common identical heat‐resistant component, defined as the antigen giving the S line. The ease of detection of the S antigen in cell lines by immunodiffusion appeared to be related to the titre of the soluble EBV‐associated CF antigen, and the evidence suggested that the soluble CF and ID antigens were probably identical. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Cancer Wiley

Identity of the soluble ebv‐associated antigens of human lymphoid cell lines

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Publisher
Wiley
Copyright
Copyright © 1972 Wiley‐Liss, Inc., A Wiley Company
ISSN
0020-7136
eISSN
1097-0215
DOI
10.1002/ijc.2910090120
Publisher site
See Article on Publisher Site

Abstract

The reactions of human sera with antigens prepared from five human lymphoid cell lines were studied by immunodiffusion. Two major precipitation lines occurred with QIMR‐WIL antigens; one (S line) due to a soluble antigen and the other (F line) due to a sedimentable antigen. A close association in human sera of precipitins producing the S line with antibody to Epstein‐Barr virus (EBV) detectable by immunofluorescence (Henle test) and by complement fixation (CF) tests indicated a specific association of the S line with EBV, but the nature of the F line was not clarified. Soluble antigens prepared from five lymphoid cell lines (including Raji) contained at least one common identical heat‐resistant component, defined as the antigen giving the S line. The ease of detection of the S antigen in cell lines by immunodiffusion appeared to be related to the titre of the soluble EBV‐associated CF antigen, and the evidence suggested that the soluble CF and ID antigens were probably identical.

Journal

International Journal of CancerWiley

Published: Jan 15, 1972

References

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