Identification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk factors for hepatocellular carcinoma

Identification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk... INTRODUCTIONHepatocellular carcinoma (HCC) is the fifth most frequent cancer and is responsible for more than half a million deaths each year, which makes it the third leading cause of cancer deaths worldwide. In China, the incidence of HCC is increasing and now accounts for 55% of all HCC cases in the world. This disease is strongly associated with several risk factors, including chronic hepatitis B virus (HBV), chronic hepatitis C virus (HCV) infection, and alcohol abuse. HBV infection is a challenging health issue in China, where about 93 million peoples are HBV carries and 30 million have chronic B hepatitis. Alcohol abuse is also on the rise in China with about 6.6% of males and 0.1% of females diagnosed with alcohol dependence. Many of these patients develop liver disease such as alcoholic hepatitis and cirrhosis thereby to subsequent carcinogenesis.The human mitochondrial genome is a 16‐kb closed circular duplex molecule that contains 37 genes, including two ribosomal RNAs and a complete set of 22 tRNAs. Because of its lack of the protection of histone protein, inefficient repaired mechanism, and generation of reactive oxygen species (ROS), mtDNA has high susceptibility to mutations and polymorphisms.Oxygen species production could cause oxidative damage that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Identification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk factors for hepatocellular carcinoma

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22299
Publisher site
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Abstract

INTRODUCTIONHepatocellular carcinoma (HCC) is the fifth most frequent cancer and is responsible for more than half a million deaths each year, which makes it the third leading cause of cancer deaths worldwide. In China, the incidence of HCC is increasing and now accounts for 55% of all HCC cases in the world. This disease is strongly associated with several risk factors, including chronic hepatitis B virus (HBV), chronic hepatitis C virus (HCV) infection, and alcohol abuse. HBV infection is a challenging health issue in China, where about 93 million peoples are HBV carries and 30 million have chronic B hepatitis. Alcohol abuse is also on the rise in China with about 6.6% of males and 0.1% of females diagnosed with alcohol dependence. Many of these patients develop liver disease such as alcoholic hepatitis and cirrhosis thereby to subsequent carcinogenesis.The human mitochondrial genome is a 16‐kb closed circular duplex molecule that contains 37 genes, including two ribosomal RNAs and a complete set of 22 tRNAs. Because of its lack of the protection of histone protein, inefficient repaired mechanism, and generation of reactive oxygen species (ROS), mtDNA has high susceptibility to mutations and polymorphisms.Oxygen species production could cause oxidative damage that

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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