Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l ‐arginine transporter

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial... The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional l‐arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns. l‐Homoarginine, l‐lysine and l‐ornithine inhibited transport of l‐arginine. The NO synthase inhibitors NG‐monomethyl‐l‐arginine and NG‐iminoethyl‐l‐ornithine also reduced l‐arginine uptake, whereas NG‐nitro‐l‐arginine and its methyl‐ester had no inhibitory effect. The ability to modulate selectively endothelial cell l‐arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l ‐arginine transporter

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Publisher
Wiley
Copyright
1992 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1992.tb09053.x
Publisher site
See Article on Publisher Site

Abstract

The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional l‐arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns. l‐Homoarginine, l‐lysine and l‐ornithine inhibited transport of l‐arginine. The NO synthase inhibitors NG‐monomethyl‐l‐arginine and NG‐iminoethyl‐l‐ornithine also reduced l‐arginine uptake, whereas NG‐nitro‐l‐arginine and its methyl‐ester had no inhibitory effect. The ability to modulate selectively endothelial cell l‐arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis.

Journal

British Journal of PharmacologyWiley

Published: Apr 1, 1992

References

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