The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional l‐arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns. l‐Homoarginine, l‐lysine and l‐ornithine inhibited transport of l‐arginine. The NO synthase inhibitors NG‐monomethyl‐l‐arginine and NG‐iminoethyl‐l‐ornithine also reduced l‐arginine uptake, whereas NG‐nitro‐l‐arginine and its methyl‐ester had no inhibitory effect. The ability to modulate selectively endothelial cell l‐arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis.
British Journal of Pharmacology – Wiley
Published: Apr 1, 1992
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