IntroductionPyridine and its derivatives are ubiquitous in nature. Nicotinic acid (NA), also known as vitamin B3, is a carboxylic derivative of pyridine and is widely distributed in living organisms, where it functions as sole carbon and nitrogen sources for some bacteria and fungi (Behrman ; Gauthier and Rittenberg ; Kaiser et al. ; Alhapel et al. ). Nicotinic acid is the precursor of biological molecule, such as pyridine cofactors, e.g. NAD and NADP, which are essential coenzymes involved in many biological processes (Behrman ). In addition, NA is widely used in industry, such as dyes (Sugimoto ) and photothermographic materials (Shi et al. ). However, the excessive use of NA can lead to high concentration of NA in waste water (Lu ), which might disrupt the balance of the ecosystem. In fact, pyridine and its derivatives have been reported to be toxic and to have a long half‐life period in environment due to their chemical stability (Kaiser et al. ; Mittal et al. ; Li et al. ).Nicotinic acid serves as a model system for the degradation of N‐heterocyclic aromatic compounds, and its biodegradation has been studied for more than 60 years (Harary ). Three different degradation pathways have been reported to date (Fig. ). Behrman et al.
Letters in Applied Microbiology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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