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Hypothetical Double‐Helical Poly(A) Formation in a Cell and Its Possible Biological Significance

Hypothetical Double‐Helical Poly(A) Formation in a Cell and Its Possible Biological Significance Arguments are presented in favor of capability of poly(A)‐tracts of cellular RNA to form double helices in vivo. It is suggested that formation of the double helix in the mRNA poly(A) tail provides the basis for such processes as polyadenylation termination, PAB I synthesis autoregulation, and stabilization of ARE‐containing mRNA by ELAV‐like proteins. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

Hypothetical Double‐Helical Poly(A) Formation in a Cell and Its Possible Biological Significance

IUBMB Life , Volume 48 (6) – Dec 1, 1999

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References (30)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 1999 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/713803577
pmid
10683761
Publisher site
See Article on Publisher Site

Abstract

Arguments are presented in favor of capability of poly(A)‐tracts of cellular RNA to form double helices in vivo. It is suggested that formation of the double helix in the mRNA poly(A) tail provides the basis for such processes as polyadenylation termination, PAB I synthesis autoregulation, and stabilization of ARE‐containing mRNA by ELAV‐like proteins.

Journal

IUBMB LifeWiley

Published: Dec 1, 1999

Keywords: Autoregulation Of Pab i Synthesis; Elav‐like Proteins; Initiation Of Translation; Polyadenylation Termination; Polya Forms; Polya Tail; Stabilization Of Are‐containing Mrna

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