Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out

Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury... Uric acid (UA) is generated as part of the normal turnover of nucleic acid. Purine bases and their nucleotides are captured by the liver and converted into xanthines, metabolized by UA, or recycled by salvage pathways or de novo synthesis. UA formation by xanthine occurs via hypoxanthine by the action of xanthine oxidase (XO), an enzyme present in the peroxisomes of most cells, which is an important source of reactive oxygen species involved in various forms of ischemic and other types of vascular injuries and chronic heart failure. In humans, higher primates, and in a particular species of dog (Dalmatians), UA is the final product of the purine catabolism. In most other mammals, the enzyme uricase further oxidizes UA to allantoin, reducing serum uric acid (SUA).UA circulates in plasma predominantly in the form of a monovalent sodium salt (urate). Hyperuricemia (HU) is commonly observed in hypertensive patients, especially in those with metabolic syndrome (MetS), where it may be a marker of insulin resistance as well as of renal dysfunction and diuretic use. Moreover, a significant association between SUA and the intrarenal resistance index measured by duplex ultrasound has been described, suggesting that HU in patients with essential hypertension (EH) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Hypertension Wiley

Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out

Loading next page...
 
/lp/wiley/hyperuricemia-and-high-blood-pressure-at-rest-and-during-exercise-U47gRzRg9Q
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
1524-6175
eISSN
1751-7176
D.O.I.
10.1111/jch.13227
Publisher site
See Article on Publisher Site

Abstract

Uric acid (UA) is generated as part of the normal turnover of nucleic acid. Purine bases and their nucleotides are captured by the liver and converted into xanthines, metabolized by UA, or recycled by salvage pathways or de novo synthesis. UA formation by xanthine occurs via hypoxanthine by the action of xanthine oxidase (XO), an enzyme present in the peroxisomes of most cells, which is an important source of reactive oxygen species involved in various forms of ischemic and other types of vascular injuries and chronic heart failure. In humans, higher primates, and in a particular species of dog (Dalmatians), UA is the final product of the purine catabolism. In most other mammals, the enzyme uricase further oxidizes UA to allantoin, reducing serum uric acid (SUA).UA circulates in plasma predominantly in the form of a monovalent sodium salt (urate). Hyperuricemia (HU) is commonly observed in hypertensive patients, especially in those with metabolic syndrome (MetS), where it may be a marker of insulin resistance as well as of renal dysfunction and diuretic use. Moreover, a significant association between SUA and the intrarenal resistance index measured by duplex ultrasound has been described, suggesting that HU in patients with essential hypertension (EH)

Journal

Journal of Clinical HypertensionWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off