Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out

Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury... Uric acid (UA) is generated as part of the normal turnover of nucleic acid. Purine bases and their nucleotides are captured by the liver and converted into xanthines, metabolized by UA, or recycled by salvage pathways or de novo synthesis. UA formation by xanthine occurs via hypoxanthine by the action of xanthine oxidase (XO), an enzyme present in the peroxisomes of most cells, which is an important source of reactive oxygen species involved in various forms of ischemic and other types of vascular injuries and chronic heart failure. In humans, higher primates, and in a particular species of dog (Dalmatians), UA is the final product of the purine catabolism. In most other mammals, the enzyme uricase further oxidizes UA to allantoin, reducing serum uric acid (SUA).UA circulates in plasma predominantly in the form of a monovalent sodium salt (urate). Hyperuricemia (HU) is commonly observed in hypertensive patients, especially in those with metabolic syndrome (MetS), where it may be a marker of insulin resistance as well as of renal dysfunction and diuretic use. Moreover, a significant association between SUA and the intrarenal resistance index measured by duplex ultrasound has been described, suggesting that HU in patients with essential hypertension (EH) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Hypertension Wiley

Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out

Loading next page...
 
/lp/wiley/hyperuricemia-and-high-blood-pressure-at-rest-and-during-exercise-U47gRzRg9Q
Publisher
Wiley
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
1524-6175
eISSN
1751-7176
D.O.I.
10.1111/jch.13227
Publisher site
See Article on Publisher Site

Abstract

Uric acid (UA) is generated as part of the normal turnover of nucleic acid. Purine bases and their nucleotides are captured by the liver and converted into xanthines, metabolized by UA, or recycled by salvage pathways or de novo synthesis. UA formation by xanthine occurs via hypoxanthine by the action of xanthine oxidase (XO), an enzyme present in the peroxisomes of most cells, which is an important source of reactive oxygen species involved in various forms of ischemic and other types of vascular injuries and chronic heart failure. In humans, higher primates, and in a particular species of dog (Dalmatians), UA is the final product of the purine catabolism. In most other mammals, the enzyme uricase further oxidizes UA to allantoin, reducing serum uric acid (SUA).UA circulates in plasma predominantly in the form of a monovalent sodium salt (urate). Hyperuricemia (HU) is commonly observed in hypertensive patients, especially in those with metabolic syndrome (MetS), where it may be a marker of insulin resistance as well as of renal dysfunction and diuretic use. Moreover, a significant association between SUA and the intrarenal resistance index measured by duplex ultrasound has been described, suggesting that HU in patients with essential hypertension (EH)

Journal

Journal of Clinical HypertensionWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off