Human respiratory syncytial virus load normalized by cell quantification as predictor of acute respiratory tract infection

Human respiratory syncytial virus load normalized by cell quantification as predictor of acute... BACKGROUNDHuman respiratory syncytial virus (HRSV) is the main etiologic agent of lower tract infections, including bronchiolitis and pneumonia, and a leading cause of hospitalizations among infants in both developing and developed countries. Recurrent infections with HRSV are common throughout life. No effective vaccine is available for prophylaxis, and ribavirin therapy is of modest benefit. Currently, our understanding of the pathogenesis of HRSV in humans is incomplete; in fact, RSV strains are separated into two major groups (A and B) on the basis of antigenic and genetic variability. This variability might contribute to the ability of the virus to cause yearly outbreaks.On the other hand, the study of the relationship among viral load, viral dynamics, and disease severity will expand our understanding of HRSV pathogenesis and they can be useful for infection management. For the quality of respiratory viral diagnosis, a rich cell collection appears to be an important prerequisite but this situation is not always present. Therefore, the main objective of this work is to analyze the prediction ability of the HRSV load normalized by the number of cells, measured by quantification of the gene of β‐globin, in samples belonging to patients with different respiratory symptoms.STUDY DESIGNPatients and samplesA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Human respiratory syncytial virus load normalized by cell quantification as predictor of acute respiratory tract infection

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25020
Publisher site
See Article on Publisher Site

Abstract

BACKGROUNDHuman respiratory syncytial virus (HRSV) is the main etiologic agent of lower tract infections, including bronchiolitis and pneumonia, and a leading cause of hospitalizations among infants in both developing and developed countries. Recurrent infections with HRSV are common throughout life. No effective vaccine is available for prophylaxis, and ribavirin therapy is of modest benefit. Currently, our understanding of the pathogenesis of HRSV in humans is incomplete; in fact, RSV strains are separated into two major groups (A and B) on the basis of antigenic and genetic variability. This variability might contribute to the ability of the virus to cause yearly outbreaks.On the other hand, the study of the relationship among viral load, viral dynamics, and disease severity will expand our understanding of HRSV pathogenesis and they can be useful for infection management. For the quality of respiratory viral diagnosis, a rich cell collection appears to be an important prerequisite but this situation is not always present. Therefore, the main objective of this work is to analyze the prediction ability of the HRSV load normalized by the number of cells, measured by quantification of the gene of β‐globin, in samples belonging to patients with different respiratory symptoms.STUDY DESIGNPatients and samplesA

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ; ;

References

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