Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.

Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the... An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high‐altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28–54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m. Measurements taken pre‐ and postexpedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (±3.6)% increase in respiratory exchange ratio measured during incremental exercise (area under curve, P > 0.01, mean ± SD) and a 2.1(±0.8) % decrease in fat tissue (P < 0.05) postexpedition. This was accompanied by an 11.6 (±1.9) % increase (P > 0.001) in VO2 max corrected to % lean mass postexpedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in‐depth characterization of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reports Wiley

Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Published by the American Physiological Society and The Physiological Society
ISSN
2051-817X
eISSN
2051-817X
D.O.I.
10.14814/phy2.13613
Publisher site
See Article on Publisher Site

Abstract

An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high‐altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28–54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m. Measurements taken pre‐ and postexpedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (±3.6)% increase in respiratory exchange ratio measured during incremental exercise (area under curve, P > 0.01, mean ± SD) and a 2.1(±0.8) % decrease in fat tissue (P < 0.05) postexpedition. This was accompanied by an 11.6 (±1.9) % increase (P > 0.001) in VO2 max corrected to % lean mass postexpedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in‐depth characterization of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth.

Journal

Physiological ReportsWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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