Human parvovirus B19 infection in organ transplant recipients

Human parvovirus B19 infection in organ transplant recipients We report a 61‐yr‐old kidney transplant recipient with human Parvovirus B19 (HPV B19) infection presenting as a severe pancytopenia 1 month after transplantation. Bone marrow aspiration revealed severe erythroid hypoplasia with giant and dystrophic proerythroblasts. Bone marrow cells were positive for HPV B19 DNA detected by polymerase chain reaction (PCR). Pancytopenia resolved shortly after administration of intravenous immunoglobulins. Nineteen cases of HPV B19 infection in organ transplant recipients have been so far reported in the literature. Immunocompromised patients should be considered at risk from developing symptomatic HPV B19 infections. In such patients, specific anti‐HPV B19 IgM and IgG antibodies may be absent or transient and therefore their negativity cannot rule out the diagnosis of HPV B19 infestation. Bone marrow smear morphological findings may suggest the diagnosis but testing for viral DNA by PCR is mandatory. Patients may spontaneously recover. However, since specific anti‐viral therapy is not currently available, intravenous immunoglobulin administration appears to be the more efficacious treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Transplantation Wiley

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Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0902-0063
eISSN
1399-0012
DOI
10.1034/j.1399-0012.1999.t01-1-130103.x
Publisher site
See Article on Publisher Site

Abstract

We report a 61‐yr‐old kidney transplant recipient with human Parvovirus B19 (HPV B19) infection presenting as a severe pancytopenia 1 month after transplantation. Bone marrow aspiration revealed severe erythroid hypoplasia with giant and dystrophic proerythroblasts. Bone marrow cells were positive for HPV B19 DNA detected by polymerase chain reaction (PCR). Pancytopenia resolved shortly after administration of intravenous immunoglobulins. Nineteen cases of HPV B19 infection in organ transplant recipients have been so far reported in the literature. Immunocompromised patients should be considered at risk from developing symptomatic HPV B19 infections. In such patients, specific anti‐HPV B19 IgM and IgG antibodies may be absent or transient and therefore their negativity cannot rule out the diagnosis of HPV B19 infestation. Bone marrow smear morphological findings may suggest the diagnosis but testing for viral DNA by PCR is mandatory. Patients may spontaneously recover. However, since specific anti‐viral therapy is not currently available, intravenous immunoglobulin administration appears to be the more efficacious treatment.

Journal

Clinical TransplantationWiley

Published: Feb 1, 1999

References

  • Dual infection with human herpesvirus type 6 and parvovirus B19 in a renal transplant recipient
    Al‐Khaldi, Al‐Khaldi; Watson, Watson; Harris, Harris; Irving, Irving
  • Pure red cell aplasia caused by parvovirus B19 infection in a renal transplant recipient
    Uemura, Uemura; Ozawa, Ozawa; Tani, Tani
  • Human parvovirus B19 infection in bone marrow transplantation patients
    Azzi, Azzi; Fanci, Fanci; Ciappi, Ciappi; Zakrzewska, Zakrzewska; Bosi, Bosi
  • Human parvovirus induced cytopenias: a report of five cases
    Saunders, Saunders; Reid, Reid; Cohen, Cohen
  • Autoimmune granulocytopenia; the detection of granulocyte autoantibodies with the immunofluorescence test
    Verheugt, Verheugt; Von dem Borne, Von dem Borne; Van Noord‐Bokhorst, Van Noord‐Bokhorst
  • Human parvovirus infection in haemophiliacs first infused with treated clotting factor concentrates
    Bartolomei Corsi, Bartolomei Corsi; Assi, Assi
  • Unusual incidence of aplastic anaemia due to parvovirus infection in renal transplant recipients
    Bertoni, Bertoni; Rosati, Rosati; Zanazzi, Zanazzi; Azzi, Azzi; Zakrewska, Zakrewska; Guidi, Guidi; Salvadori, Salvadori

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