HORMONAL CONTROL OF METABOLISM IN TRAUMA AND SEPSIS

HORMONAL CONTROL OF METABOLISM IN TRAUMA AND SEPSIS K . N . FRAYN MRC Trauma Unir, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT and Hope Hospital (University of Manchester School of Medicine), Eccles Old Road, Salford M6 8 H D , U K (Received 13 January 1986: rerurned for rPcisivn 21 Junuury 1986;Jinully revised 18 Februury 1986: uccepred 19 February 1986) INTRODUCTION The care of the injured or severely septic patient is often centred around the repair of his injuries or treatment of his infection. However, i t has long been recognized that the f conditions of injury and sepsis are associated with metabolic changes affecting all parts o the body. and also that these responses change with time in a generally predictable way. The scientific study of the metabolic responses to trauma is often considered to have begun with David Cuthbertson’s observation of the marked rise in urinary nitrogen excretion after longbone fractures (Cuthbertson, 1930). It has received special impetus over the past decade with the recognition of the important role of nutrition in the treatment of these conditions. However, the hormonal background to these metabolic responses is by no means fully understood. The purpose of this review is to summarize our http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Endocrinology Wiley

HORMONAL CONTROL OF METABOLISM IN TRAUMA AND SEPSIS

Clinical Endocrinology, Volume 24 (5) – May 1, 1986

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Publisher
Wiley
Copyright
Copyright © 1986 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0300-0664
eISSN
1365-2265
DOI
10.1111/j.1365-2265.1986.tb03288.x
Publisher site
See Article on Publisher Site

Abstract

K . N . FRAYN MRC Trauma Unir, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT and Hope Hospital (University of Manchester School of Medicine), Eccles Old Road, Salford M6 8 H D , U K (Received 13 January 1986: rerurned for rPcisivn 21 Junuury 1986;Jinully revised 18 Februury 1986: uccepred 19 February 1986) INTRODUCTION The care of the injured or severely septic patient is often centred around the repair of his injuries or treatment of his infection. However, i t has long been recognized that the f conditions of injury and sepsis are associated with metabolic changes affecting all parts o the body. and also that these responses change with time in a generally predictable way. The scientific study of the metabolic responses to trauma is often considered to have begun with David Cuthbertson’s observation of the marked rise in urinary nitrogen excretion after longbone fractures (Cuthbertson, 1930). It has received special impetus over the past decade with the recognition of the important role of nutrition in the treatment of these conditions. However, the hormonal background to these metabolic responses is by no means fully understood. The purpose of this review is to summarize our

Journal

Clinical EndocrinologyWiley

Published: May 1, 1986

References

  • Influence of the burn wound on peripheral circulation in thermally injured patients
    Aulick, Aulick; Wilmore, Wilmore; Mason, Mason; Pruitt, Pruitt
  • Studies on the mechanism of insulin resistance after injury in the mouse
    Frayn, Frayn; Le Marchand‐Brustel, Le Marchand‐Brustel; Freychet, Freychet
  • Plasma somatomedin activity after injury in man and its relationship to other hormonal and metabolic changes
    Frayn, Frayn; Price, Price; Maycock, Maycock; Carroll, Carroll
  • Regulation of pancreatic insulin and glucagon secretion
    Gerich, Gerich; Charles, Charles; Grodsky, Grodsky
  • The relationship of plasma glucagon to the hyperglycaemia and hyperinsulinaemia of surgical operation
    Giddings, Giddings; O'Connor, O'Connor; Rowlands, Rowlands; Mangnall, Mangnall; Clark, Clark
  • Carbohydrate metabolism in man: effect of elective operations and major injury
    Long, Long; Spencer, Spencer; Kinney, Kinney; Geigy, Geigy
  • The effect of sepsis on the oxidation of carbohydrate and fat
    Stoner, Stoner; Little, Little; Frayn, Frayn; Elebute, Elebute; Tresadern, Tresadern; Gross, Gross
  • On the mechanism of glucose release from the muscle of juvenile diabetics in acute insulin deficiency
    Wicklmayr, Wicklmayr; Dietze, Dietze

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