Homozygous HLA‐G*0105N healthy individuals indicate that membrane‐anchored HLA‐G1 molecule is not necessary for survival

Homozygous HLA‐G*0105N healthy individuals indicate that membrane‐anchored HLA‐G1 molecule... Abstract: HLA‐G is expected to play an important role during fetal development. Recently, a healthy individual homozygous for the HLA‐G*0105N allele has been described, suggesting that HLA‐G expression was not essential for fetal survival. We now report studies of one family with five healthy siblings homozygous for HLA‐G*0105N, who had been normally delivered; three of these siblings were females who also had normal deliveries. In addition, HLA‐G*0105N cDNA has been fully sequenced, and normal G1 membrane anchored protein cannot be translated since after the codon 130 cytosine deletion (exon 3) a reading frameshift is observed leading to the existence of premature stop codon at position 189 (beginning of exon 4). Other protein isoforms (G2, G3 and G6), all containing the leader peptide and the α1 domain, are possible and their messenger mRNAs were found; any of these may undertake the necessary HLA‐G functions. Our data show that the membrane anchored HLA‐G molecule is not necessary in either mother or fetus for a normal pregnancy and survival. Also, individuals homozygous for HLA‐G*0105N are healthy and with no indications of immunodeficiency or autoimmunity ( ). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tissue Antigens Wiley

Homozygous HLA‐G*0105N healthy individuals indicate that membrane‐anchored HLA‐G1 molecule is not necessary for survival

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0001-2815
eISSN
1399-0039
DOI
10.1034/j.1399-0039.2000.560305.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: HLA‐G is expected to play an important role during fetal development. Recently, a healthy individual homozygous for the HLA‐G*0105N allele has been described, suggesting that HLA‐G expression was not essential for fetal survival. We now report studies of one family with five healthy siblings homozygous for HLA‐G*0105N, who had been normally delivered; three of these siblings were females who also had normal deliveries. In addition, HLA‐G*0105N cDNA has been fully sequenced, and normal G1 membrane anchored protein cannot be translated since after the codon 130 cytosine deletion (exon 3) a reading frameshift is observed leading to the existence of premature stop codon at position 189 (beginning of exon 4). Other protein isoforms (G2, G3 and G6), all containing the leader peptide and the α1 domain, are possible and their messenger mRNAs were found; any of these may undertake the necessary HLA‐G functions. Our data show that the membrane anchored HLA‐G molecule is not necessary in either mother or fetus for a normal pregnancy and survival. Also, individuals homozygous for HLA‐G*0105N are healthy and with no indications of immunodeficiency or autoimmunity ( ).

Journal

Tissue AntigensWiley

Published: Sep 1, 2000

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