Abstract: The aim of this study was to compare the frequencies of five HLA‐E alleles in 82 women with recurrent spontaneous abortions with that of 150 random Danish controls. PCR sequence‐specific oligonucleotide typing was carried out to detect polymorphism in exons 2 and 3 of the HLA‐E gene. In informative samples sequencing of these two exons was also undertaken to confirm the presence of the HLA‐E*01031 allele. HLA‐E*0101, HLA‐ E*01032 and HLA‐E*01031 were detected with frequencies of 56.7%, 33.6% and 9.6% in controls and 58,5%, 32.9% and 8.5% in patients with recurrent abortion, respectively. No HLA‐E*0102 and E*0104 alleles could be detected. Since the HLA‐E allele distribution was similar in women with recurrent spontaneous abortion and controls, it is suggested that maternal HLA‐E polymorphism per se does not play any role in the pathogenesis of this disorder of pregnancy.
Tissue Antigens – Wiley
Published: Dec 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera