High NK Cell Activity in Early Pregnancy Correlates with Subsequent Abortion with Normal Chromosomes in Women with Recurrent Abortion

High NK Cell Activity in Early Pregnancy Correlates with Subsequent Abortion with Normal... PROBLEM: The aim of this study was to assess the role of natural killer (NK) cells in pregnant women with a history of recurrent spontaneous abortion (RSA). METHOD OF STUDY: Consecutive 66 pregnant women with a history of RSA were prospectively assessed for peripheral NK cell activity, percentage of the NK cell subsets, and subsequent pregnancy outcome. RESULTS: NK cell activity in women with subsequent live birth (group I) at 4–5 gestational weeks (GW) (mean±SD, 32.5±12.3%) significantly decreased at 6–7 GW (28.1±12.1%) and at 8–9 GW (28.0±11.8%). NK cell activity in women with subsequent abortion with normal chromosomes (group II) at 6–7 GW (41.2±19.0%) was significantly higher than that in group I women, while NK cell activity at 6–7 GW in women with subsequent abortion with abnormal chromosomes (group III) was the same as the level in group I women. CONCLUSIONS: High NK cell activity at 6–7 GW correlates with subsequent abortion with normal chromosomes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Reproductive Immunology Wiley

High NK Cell Activity in Early Pregnancy Correlates with Subsequent Abortion with Normal Chromosomes in Women with Recurrent Abortion

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Publisher
Wiley
Copyright
Copyright © 2001 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1046-7408
eISSN
1600-0897
DOI
10.1111/j.8755-8920.2001.460203.x
Publisher site
See Article on Publisher Site

Abstract

PROBLEM: The aim of this study was to assess the role of natural killer (NK) cells in pregnant women with a history of recurrent spontaneous abortion (RSA). METHOD OF STUDY: Consecutive 66 pregnant women with a history of RSA were prospectively assessed for peripheral NK cell activity, percentage of the NK cell subsets, and subsequent pregnancy outcome. RESULTS: NK cell activity in women with subsequent live birth (group I) at 4–5 gestational weeks (GW) (mean±SD, 32.5±12.3%) significantly decreased at 6–7 GW (28.1±12.1%) and at 8–9 GW (28.0±11.8%). NK cell activity in women with subsequent abortion with normal chromosomes (group II) at 6–7 GW (41.2±19.0%) was significantly higher than that in group I women, while NK cell activity at 6–7 GW in women with subsequent abortion with abnormal chromosomes (group III) was the same as the level in group I women. CONCLUSIONS: High NK cell activity at 6–7 GW correlates with subsequent abortion with normal chromosomes.

Journal

American Journal of Reproductive ImmunologyWiley

Published: Aug 1, 2001

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