Abstract: Primary astrocyte cultures from neonatal rat brains show uptake of (3H)norepinephrine ((3H)NE). This uptake has a high‐affinity component with an apparent Km of approximately 3 × 10−7 M. At 10−7 M (3H)NE both the initial rate of uptake and steady‐state content of (3H)NE is inhibited by up to 95% by omission of external Na+. The Na+‐dependent component of this uptake is totally inhibited by the tricyclic antidepressants desipramine (DMI) and amitryptyline with IC50 values of 2 × 10−9 and 4 × 10−8 M, respectively. Inhibition of (3H)NE uptake by DMI shows competitive kinetics. These characteristics are essentially identical to those found for high‐affinity uptake of NE in total membrane or synaptosome fractions from rodent brains and suggests that such uptake in neural tissue is not exclusively neuronal.
Journal of Neurochemistry – Wiley
Published: May 1, 1983
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