Hepatitis G viral RNA in serum and in peripheral blood mononuclear cells and its relation to HCVRNA in patients with clotting disorders. Sheng L, Soumillion A, Peerlinck K, Verslype C, Lin L, van Pelt J, Hess G, Vermylen J, Yap SH. Thromb Haemostas 1997; 77: 868Â±72. The hepatitis G virus (HGV) has recently been identiÂ®ed as a new member of the Flaviviridae family. Infection by this virus is thought to be associated with blood borne hepatitis. In this study, the presence of HCV- and HGV-RNAs in serum or plasma (175 patients) and in peripheral blood mononuclear cells (PBMC) (133 patients) was investigated in patients with clotting disorders using a sensitive reverse transcriptase polymerase chain reaction (RT-PCR). HGVRNA was detected in serum of 26 patients (14.8%). In apparently healthy blood donors, serum HGV-RNA was detected in 4 of 358 individuals investigated (1.12%). Ninety two percent of the 26 serum HGV-RNA positive patients had coinfection with the hepatitis C virus (HCV), especially with HCV genotype Ib, the most common genotype in Belgium. Of these coinfected patients, 15 (62.5%) showed elevated serum ALT levels. Two patients who were solely infected with HGV had normal serum ALT. HGV-RNA in PBMC was found
Haemophilia – Wiley
Published: Jul 1, 1997
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