INTRODUCTIONPeriodontitis, one of the most widespread diseases worldwide, involves loss of tooth‐supporting structures in varying degrees and may cause loss of tooth, which deteriorates the quality of life (Cunha‐Cruz, Hujoel, & Kressin, ). Considering the age‐related prevalence of periodontitis, managing this disease has become increasingly important in the current aged and ultra‐aged populations (Kassebaum et al., ).Non‐surgical, surgical, and antimicrobial approaches or a combination of these approaches are conventional modes for resolution of periodontitis in a routine clinical setting (Dentino, Lee, Mailhot, & Hefti, ). Disappointingly, while these methods are effective for controlling periodontal disease, they are not sufficient for predictably achieving regeneration (Zeichner‐David, ). Thus, various bioactive agents have been extensively explored. Growth factors, such as fibroblast growth factor‐2, platelet‐derived growth factor‐BB, and growth/differentiation factor‐5, have been shown to have favorable preclinical and clinical results (Cochran et al., ; Lee & Wikesjo, ; Nevins et al., ; Takayama, Murakami, Shimabukuro, Kitamura, & Okada, ), but they are still not a commonly used modality. Enamel matrix derivative has also been extensively investigated (Miron et al., ). Numerous studies have supported the regenerative outcome of enamel matrix derivative, but its effect has only been validated in limited environments (Miron et
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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