“Graft to” Synthesis and Ibuprofen‐Loading Performance of pH‐Sensitive PMAA –Silica Hybrid Nanoparticles with Controlled Bimodal Mesopores

“Graft to” Synthesis and Ibuprofen‐Loading Performance of pH‐Sensitive PMAA –Silica... Bimodal mesoporous silicas (BMMs) have been proved to be a good drug‐loaded carrier. However, it did not provide stimuli sensitivity or controlled release performance yet. In the present work, a “smart” mesoporous silica‐based pH‐dependent (poly(methacrylic acid))–silica hybrid nanoparticles (P/NN‐BMMs) drug delivery system was developed and evaluated with ibuprofen (IBU) as a model drug. P/NN‐BMMs were prepared by coating poly(methacrylic acid) (PMAA) onto amino‐modified surface of BMMs via the “graft to” strategy. The structure and texture of resultant hybrid nanoparticles were determined with X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, thermogravimetric analysis, N2 sorption isotherms, and elemental analysis. The PMAA acts as a molecular switch to achieve controlled drug release and the amount of grafted‐PMAA can remarkably affect its performance. The drug‐loading rate is decreased markedly with the increasing of the amount of grafted‐PMAA, meanwhile, the drug‐loading kinetics on P/NN‐BMMs fits Korsmeyer–Peppas model. In addition, the drug‐release amount from drug‐loaded P/NN‐BMMs is pH dependent, showing an increasing tendency with the increase of pH value. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:4299–4306, 2015 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmaceutical Science Wiley

“Graft to” Synthesis and Ibuprofen‐Loading Performance of pH‐Sensitive PMAA –Silica Hybrid Nanoparticles with Controlled Bimodal Mesopores

Loading next page...
 
/lp/wiley/graft-to-synthesis-and-ibuprofen-loading-performance-of-ph-sensitive-GZor4VxZO2
Publisher
Wiley
Copyright
Copyright © 2015 Wiley Periodicals, Inc., A Wiley Company
ISSN
0022-3549
eISSN
1520-6017
D.O.I.
10.1002/jps.24668
Publisher site
See Article on Publisher Site

Abstract

Bimodal mesoporous silicas (BMMs) have been proved to be a good drug‐loaded carrier. However, it did not provide stimuli sensitivity or controlled release performance yet. In the present work, a “smart” mesoporous silica‐based pH‐dependent (poly(methacrylic acid))–silica hybrid nanoparticles (P/NN‐BMMs) drug delivery system was developed and evaluated with ibuprofen (IBU) as a model drug. P/NN‐BMMs were prepared by coating poly(methacrylic acid) (PMAA) onto amino‐modified surface of BMMs via the “graft to” strategy. The structure and texture of resultant hybrid nanoparticles were determined with X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, thermogravimetric analysis, N2 sorption isotherms, and elemental analysis. The PMAA acts as a molecular switch to achieve controlled drug release and the amount of grafted‐PMAA can remarkably affect its performance. The drug‐loading rate is decreased markedly with the increasing of the amount of grafted‐PMAA, meanwhile, the drug‐loading kinetics on P/NN‐BMMs fits Korsmeyer–Peppas model. In addition, the drug‐release amount from drug‐loaded P/NN‐BMMs is pH dependent, showing an increasing tendency with the increase of pH value. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:4299–4306, 2015

Journal

Journal of Pharmaceutical ScienceWiley

Published: Dec 1, 2015

Keywords: ; ; ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off