Bimodal mesoporous silicas (BMMs) have been proved to be a good drug‐loaded carrier. However, it did not provide stimuli sensitivity or controlled release performance yet. In the present work, a “smart” mesoporous silica‐based pH‐dependent (poly(methacrylic acid))–silica hybrid nanoparticles (P/NN‐BMMs) drug delivery system was developed and evaluated with ibuprofen (IBU) as a model drug. P/NN‐BMMs were prepared by coating poly(methacrylic acid) (PMAA) onto amino‐modified surface of BMMs via the “graft to” strategy. The structure and texture of resultant hybrid nanoparticles were determined with X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, thermogravimetric analysis, N2 sorption isotherms, and elemental analysis. The PMAA acts as a molecular switch to achieve controlled drug release and the amount of grafted‐PMAA can remarkably affect its performance. The drug‐loading rate is decreased markedly with the increasing of the amount of grafted‐PMAA, meanwhile, the drug‐loading kinetics on P/NN‐BMMs fits Korsmeyer–Peppas model. In addition, the drug‐release amount from drug‐loaded P/NN‐BMMs is pH dependent, showing an increasing tendency with the increase of pH value. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:4299–4306, 2015
Journal of Pharmaceutical Science – Wiley
Published: Dec 1, 2015
Keywords: ; ; ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera