Glucose tolerance and insulin sensitivity in ponies and Standardbred horses

Glucose tolerance and insulin sensitivity in ponies and Standardbred horses Summary The existence of an innate insulin insensitivity in ponies was investigated and compared with the situation in larger breeds of horse. Ponies that were fat or had previously suffered laminitis were found to be far more intolerant to oral glucose loading (1 g/kg bodyweight (bwt)) than normal ponies or Standardbreds. These ponies also exhibited a far greater response in plasma insulin levels after glucose loading. Insulin response tests (0.4 iu/kg bwt insulin intravenously) showed only a minimal and very protracted response in both the fat and laminitic groups. The relevance of these findings in regulation of carbohydrate and lipid metabolism, and their role in the pathogenesis of hyperlipaemia, are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

Glucose tolerance and insulin sensitivity in ponies and Standardbred horses

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Publisher
Wiley
Copyright
© 1986 EVJ Ltd
ISSN
0425-1644
eISSN
2042-3306
D.O.I.
10.1111/j.2042-3306.1986.tb03556.x
Publisher site
See Article on Publisher Site

Abstract

Summary The existence of an innate insulin insensitivity in ponies was investigated and compared with the situation in larger breeds of horse. Ponies that were fat or had previously suffered laminitis were found to be far more intolerant to oral glucose loading (1 g/kg bodyweight (bwt)) than normal ponies or Standardbreds. These ponies also exhibited a far greater response in plasma insulin levels after glucose loading. Insulin response tests (0.4 iu/kg bwt insulin intravenously) showed only a minimal and very protracted response in both the fat and laminitic groups. The relevance of these findings in regulation of carbohydrate and lipid metabolism, and their role in the pathogenesis of hyperlipaemia, are discussed.

Journal

Equine Veterinary JournalWiley

Published: Mar 1, 1986

References

  • Diabetes and obesity: thrifty mutants
    Coleman, Coleman
  • Diabetic hypertriglyceridemia
    Reaven, Reaven; Greenfield, Greenfield
  • The oral glucose tolerance test in the horse
    Roberts, Roberts; Hill, Hill

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