INTRODUCTIONTemporomandibular joint osteoarthritis (TMJ OA), defined as a degenerative disease, is characterized by cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. TMJ OA is also known as a common subtype of temporomandibular disorders (TMDs) and primarily afflicts women aged 20–40 years. Patients with TMJ OA usually have limitation of motion, pain of joint and muscle, and masticatory functional impairment, and thus, quality of life is affected seriously (Zarb & Carlsson, ). Currently, conservative treatments are the prior choices for TMJ OA, including physical therapies, occlusal splints, NSAIDs, and arthrocentesis with corticosteroid (de Souza, Lovato da Silva, Nasser, Fedorowicz, & Al‐Muharraqi, ), whose effects are mainly symptomatic.Hyaluronic acid (HA) is an ingredient of normal synovial fluid and cartilage matrix of TMJ, which can lubricate the joint and thereby reduce friction and stress on the joint cartilage to maintain TMJ homeostasis (Guarda‐Nardini et al., ). Intra‐articular injection of HA is to supplement HA in the joint with exogenous HA, which has been suggested as a therapy for OA (Bannuru et al., ). An open‐label study of 76 TMJ OA patients supported the benefits of serial HA injections after 6‐month follow‐up (Manfredini, Bonnini, Arboretti, & Guarda‐Nardini, ).Glucosamine (GS) is classified as a “dietary supplement”
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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