Ginkgolic Acid Inhibits Invasion and Migration and TGF‐β‐Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

Ginkgolic Acid Inhibits Invasion and Migration and TGF‐β‐Induced EMT of Lung Cancer Cells... ORIGINAL RESEARCH ARTICLE 346 Journal of Journal of Cellular Cellular Physiology Physiology Ginkgolic Acid Inhibits Invasion and Migration and TGF-b-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation 1 1 1 1 SEUNG HO BAEK, JEONG-HYEON KO, JONG HYUN LEE, CHULWON KIM, 1 1 1 1 HANWOOL LEE, DONGWOO NAM, JUNHEE LEE, SEOK-GEUN LEE, 1 1 2 WOONG MO YANG, JAE-YOUNG UM, GAUTAM SETHI, * AND KWANG SEOK AHN ** College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and the related underlying mechanism(s) of its actions. We found that ginkgolic acid C15:1 (GA C15:1) inhibited cell proliferation, invasion, and migration in both A549 and H1299 lung cancer cells. GA C15:1 also suppressed the expression of EMT related genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist and Snail) and suppressed TGF-b-induced EMT as assessed by reduced expression of mesenchymal markers (Fibronectin, Vimentin, N-cadherin), MMP-9, MMP-2, Twist and Snail. However, GA C15:1 did not affect the expression of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular Physiology Wiley

Ginkgolic Acid Inhibits Invasion and Migration and TGF‐β‐Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

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Publisher
Wiley
Copyright
© 2017 Wiley Periodicals, Inc.
ISSN
0021-9541
eISSN
1097-4652
DOI
10.1002/jcp.25426
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ARTICLE 346 Journal of Journal of Cellular Cellular Physiology Physiology Ginkgolic Acid Inhibits Invasion and Migration and TGF-b-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation 1 1 1 1 SEUNG HO BAEK, JEONG-HYEON KO, JONG HYUN LEE, CHULWON KIM, 1 1 1 1 HANWOOL LEE, DONGWOO NAM, JUNHEE LEE, SEOK-GEUN LEE, 1 1 2 WOONG MO YANG, JAE-YOUNG UM, GAUTAM SETHI, * AND KWANG SEOK AHN ** College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and the related underlying mechanism(s) of its actions. We found that ginkgolic acid C15:1 (GA C15:1) inhibited cell proliferation, invasion, and migration in both A549 and H1299 lung cancer cells. GA C15:1 also suppressed the expression of EMT related genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist and Snail) and suppressed TGF-b-induced EMT as assessed by reduced expression of mesenchymal markers (Fibronectin, Vimentin, N-cadherin), MMP-9, MMP-2, Twist and Snail. However, GA C15:1 did not affect the expression of

Journal

Journal of Cellular PhysiologyWiley

Published: Feb 1, 2017

References

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