ORIGINAL RESEARCH ARTICLE 346 Journal of Journal of Cellular Cellular Physiology Physiology Ginkgolic Acid Inhibits Invasion and Migration and TGF-b-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation 1 1 1 1 SEUNG HO BAEK, JEONG-HYEON KO, JONG HYUN LEE, CHULWON KIM, 1 1 1 1 HANWOOL LEE, DONGWOO NAM, JUNHEE LEE, SEOK-GEUN LEE, 1 1 2 WOONG MO YANG, JAE-YOUNG UM, GAUTAM SETHI, * AND KWANG SEOK AHN ** College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and the related underlying mechanism(s) of its actions. We found that ginkgolic acid C15:1 (GA C15:1) inhibited cell proliferation, invasion, and migration in both A549 and H1299 lung cancer cells. GA C15:1 also suppressed the expression of EMT related genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist and Snail) and suppressed TGF-b-induced EMT as assessed by reduced expression of mesenchymal markers (Fibronectin, Vimentin, N-cadherin), MMP-9, MMP-2, Twist and Snail. However, GA C15:1 did not affect the expression of
Journal of Cellular Physiology – Wiley
Published: Feb 1, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera