Shigeo Hayashi,1,2,3* Kei Ito,4 Yukiko Sado,1 Misako Taniguchi,1 Ai Akimoto,3 Hiroko Takeuchi,1 Toshiro Aigaki,5 Fumio Matsuzaki,3,6 Hideki Nakagoshi,7 Teiichi Tanimura,8 Ryu Ueda,1,2,9 Tadashi Uemura,10 Motojiro Yoshihara,11 and Satoshi Goto1,2,9 National Institute of Genetics, Mishima, Shizuoka-ken, Japan Department of Genetics, Graduate University for Advanced Studies, Mishima, Shizuoka-ken, Japan 3 Riken Center for Developmental Biology, Kobe, Hyogo, Japan 4 National Institute for Basic Biology Myodaiji, Okazaki, Aichi, Japan 5 Department of Biology, Tokyo Metropolitan University, Tokyo, Japan 6 Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan 7 Okayama University Graduate School of Natural Science and Technology, Okayama, Japan 8 Department of Biology, Graduate School of Sciences, Kyushu University, Ropponmatsu, Fukuoka, Japan 9 Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan 10 Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan 11 Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Received 25 June 2002; Accepted 5 July 2002 Regulatory genes important for development and physiology are often transcribed in tissue- and temporaryspeciï¬c manners. Differential gene expression is therefore an important aspect of genome function in multicellular organisms. Transcriptional enhancers are often difï¬cult to identify by a simple
Genesis: the Journal of Genetics and Development – Wiley
Published: Sep 1, 2002
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