Genomic expansion and clustering of ZAD‐containing C2H2 zinc‐finger genes in Drosophila

Genomic expansion and clustering of ZAD‐containing C2H2 zinc‐finger genes in Drosophila C2H2 zinc‐finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila genome, corresponding to ∼2.3% of the annotated genes. Approximately 29% of the Drosophila ZFPs are evolutionary conserved in humans and/or Caenorhabditis elegans. In addition, ∼28% of the ZFPs contain an N‐terminal zinc‐finger‐associated C4DM domain (ZAD) consisting of ∼75 amino acid residues. The ZAD is restricted to ZFPs of dipteran and closely related insects. The evolutionary restriction, an expansion of ZAD‐containing ZFP genes in the Drosophila genome and their clustering at few chromosomal sites are features reminiscent of vertebrate KRAB‐ZFPs. ZADs are likely to represent protein–protein interaction domains. We propose that ZAD‐containing ZFP genes participate in transcriptional regulation either directly or through site‐specific modification and/or regulation of chromatin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png EMBO Reports Wiley

Genomic expansion and clustering of ZAD‐containing C2H2 zinc‐finger genes in Drosophila

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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
1469-221X
eISSN
1469-3178
D.O.I.
10.1093/embo-reports/kvf243
Publisher site
See Article on Publisher Site

Abstract

C2H2 zinc‐finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila genome, corresponding to ∼2.3% of the annotated genes. Approximately 29% of the Drosophila ZFPs are evolutionary conserved in humans and/or Caenorhabditis elegans. In addition, ∼28% of the ZFPs contain an N‐terminal zinc‐finger‐associated C4DM domain (ZAD) consisting of ∼75 amino acid residues. The ZAD is restricted to ZFPs of dipteran and closely related insects. The evolutionary restriction, an expansion of ZAD‐containing ZFP genes in the Drosophila genome and their clustering at few chromosomal sites are features reminiscent of vertebrate KRAB‐ZFPs. ZADs are likely to represent protein–protein interaction domains. We propose that ZAD‐containing ZFP genes participate in transcriptional regulation either directly or through site‐specific modification and/or regulation of chromatin.

Journal

EMBO ReportsWiley

Published: Dec 1, 2002

References

  • Profile hidden Markov models
    Eddy, S.R.
  • Gene2EST: a BLAST2 server for searching expressed sequence tag (EST) databases with eukaryotic gene‐sized queries
    Gemünd, C.; Ramu, C.; Altenberg‐Greulich, B.; Gibson, T.J.
  • Two types of zinc fingers are required for dimerization of the Serendipity δ transcriptional activator
    Payre, F.; Buono, P.; Vanzo, N.; Vincent, A.
  • The taxonomy of developmental control in Caenorhabditis elegans
    Ruvkun, G.; Hobert, O.
  • Nuclear receptors in nematodes: themes and variations
    Sluder, A.E.; Maina, C.V.

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