1INTRODUCTIONGastric cancer is one of the major malignancies accounting for a notable amount of morbidity and mortality around the world, especially in Asian countries, such as China. Despite published evidence indicating that the incidence of gastric cancer has decreased over the past several decades in some European countries, it is still a leading cause of cancer death in both sexes worldwide. The signs and symptoms of gastric cancer often emerge late in the advanced stages of the disease, thus treatment options are usually limited. The management of the patient's resource availability also differs between countries. These factors contribute to a poor prognosis of gastric cancer due to a lack of an effective treatment regimen and correlation data statistics shows the five‐year survival rate of gastric cancer is only 24–25%. Despite recent progress in gastrectomy, chemotherapy and radiotherapy, a large number of all advanced stage gastric cancer patients die of recurrence, even after undergoing curative gastrectomy and adjuvant treatment. To address these issues and to aid in the development of novel targeted therapies for gastric cancer, it is imperative to elucidate the regulatory mechanisms and the molecular alterations modulating tumorigenesis.The pathogenesis of gastric cancer is complex and involves multiple factors,
Asia-Pacific Journal of Clinical Oncology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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