Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African... Avoiding the devastating implications of the soaring global burden of hypertension has become the focus of a great deal of attention recently. Given these implications, significant effort has been paid to understand better the factors leading to this global public health crisis. Across the African continent, the prevalence of hypertension is on the rise, with reported rates as high as 46% in some populations in South Africa. This higher than average prevalence of hypertension has been reported across the African diaspora including populations within the United States, the United Kingdom, and the Caribbean. Thus, the increased prevalence of hypertension coupled with the enhanced sequelae of the target organ damage associated with an elevated blood pressure in persons of African ancestry calls into question the role that genetics might play in the preponderance of hypertension among African populations.The genetics governing the phenotypic state, that is, raised blood pressure and hypertension, is fascinating but equally complex and enigmatic with several advances having been made over the last 30 years. On the one hand are rare monogenetic hypertensive syndromes, which at best account for less than 5% of all cases of hypertension. These syndromes frequently demonstrate traditional Mendelian genetics with the inherence of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Hypertension Wiley

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
1524-6175
eISSN
1751-7176
D.O.I.
10.1111/jch.13249
Publisher site
See Article on Publisher Site

Abstract

Avoiding the devastating implications of the soaring global burden of hypertension has become the focus of a great deal of attention recently. Given these implications, significant effort has been paid to understand better the factors leading to this global public health crisis. Across the African continent, the prevalence of hypertension is on the rise, with reported rates as high as 46% in some populations in South Africa. This higher than average prevalence of hypertension has been reported across the African diaspora including populations within the United States, the United Kingdom, and the Caribbean. Thus, the increased prevalence of hypertension coupled with the enhanced sequelae of the target organ damage associated with an elevated blood pressure in persons of African ancestry calls into question the role that genetics might play in the preponderance of hypertension among African populations.The genetics governing the phenotypic state, that is, raised blood pressure and hypertension, is fascinating but equally complex and enigmatic with several advances having been made over the last 30 years. On the one hand are rare monogenetic hypertensive syndromes, which at best account for less than 5% of all cases of hypertension. These syndromes frequently demonstrate traditional Mendelian genetics with the inherence of

Journal

Journal of Clinical HypertensionWiley

Published: Jan 1, 2018

References

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