Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree

Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in... We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala → Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p <0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3–22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree

Loading next page...
 
/lp/wiley/genetic-variation-in-paraoxonase-2-is-associated-with-variation-in-IxExPXvcV8

References (29)

Publisher
Wiley
Copyright
1998 Blackwell Munksgaard
ISSN
0009-9163
eISSN
1399-0004
DOI
10.1111/j.1399-0004.1998.tb03752.x
Publisher site
See Article on Publisher Site

Abstract

We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala → Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p <0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3–22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.

Journal

Clinical GeneticsWiley

Published: Nov 1, 1998

Keywords: genetic variation; paraoxonase-2; plasma lipoprotein

There are no references for this article.