Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Antikainen, S. Murtomäki, M. Syvänne, R. Pahlman, E. Tahvanainen, M. Jauhiainen, M. Frick, C. Ehnholm (1996)
The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.The Journal of clinical investigation, 98 4
Robert Hegele, J. Brunt, Philip Connelly (1995)
Genetic variation on chromosome 1 associated with variation in body fat distribution in men.Circulation, 92 5
E. Pavković, V. Simeon, E. Reiner, M. Sučić, V. Lipovac (1993)
Serum paraoxonase and cholinesterase activities in individuals with lipid and glucose metabolism disorders.Chemico-biological interactions, 87 1-3
M. Odawara, M. Odawara, Y. Tachi, K. Yamashita (1997)
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.The Journal of clinical endocrinology and metabolism, 82 7
R. Hegele, A. Evans, L. Tu, Gregory Ip, J. Brunt, P. Connelly (1994)
A gene-gender interaction affecting plasma lipoproteins in a genetic isolate.Arteriosclerosis and thrombosis : a journal of vascular biology, 14 5
D. Sanghera, N. Saha, C. Aston, M. Kamboh (1997)
Genetic polymorphism of paraoxonase and the risk of coronary heart disease.Arteriosclerosis, thrombosis, and vascular biology, 17 6
M. Blatter, Richard James, S. Messmer, Francisco Barja, Daniel Pometta (1993)
Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase.European journal of biochemistry, 211 3
(1995)
SAS/STAT Guide for personal computers (version 6.12)
M. Mackness, D. Harty, D. Bhatnagar, P. Winocour, S. Arrol, M. Ishola, P. Durrington (1991)
Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus.Atherosclerosis, 86 2-3
S. Primo-Parmo, R. Sorenson, J. Teiber, B. Du (1996)
The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.Genomics, 33 3
Robert Hegele, J. Brunt, Philip Connelly (1995)
Multiple genetic determinants of variation of plasma lipoproteins in Alberta Hutterites.Arteriosclerosis, thrombosis, and vascular biology, 15 7
R. Hegele, J. Brunt, P. Connelly (1994)
A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate.Circulation, 90 5
Hegele Ra, W. Breckenridge, J. Brunt, P. Connelly (1997)
Genetic Variation in Factor VII Associated with Variation in Plasma Lipoprotein(a) ConcentrationArteriosclerosis, Thrombosis, and Vascular Biology, 17
R. Hegele, J. Brunt, P. Connelly (1995)
A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate.Arteriosclerosis, thrombosis, and vascular biology, 15 1
R. Hegele, P. Connelly, A. Hanley, F. Sun, S. Harris, B. Zinman (1997)
Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians.Arteriosclerosis, thrombosis, and vascular biology, 17 6
M. Mackness, B. Mackness, P. Durrington, P. Connelly, R. Hegele (1996)
Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteinsCurrent Opinion in Lipidology, 7
R. Hegele (1997)
The genetic basis of atherosclerosisInternational Journal of Clinical and Laboratory Research, 27
R. Hegele (1997)
Candidate genes, small effects, and the prediction of atherosclerosis.Critical reviews in clinical laboratory sciences, 34 4
N. Schork (1997)
Genetically complex cardiovascular traits. Origins, problems, and potential solutions.Hypertension, 29 1 Pt 2
(1979)
Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose IntoleranceDiabetes, 28
S. Herrmann, H. Blanc, O. Poirier, D. Arveiler, G. Luc, A. Evans, P. Marques-Vidal, J. Bard, F. Cambien (1996)
The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study.Atherosclerosis, 126 2
N. Saha, A. Roy, S. Teo, J. Tay, S. Ratnam (1991)
Influence of serum paraoxonase polymorphism on serum lipids and apolipoproteinsClinical Genetics, 40
Lander (1994)
Genetic dissection of complex traitsScience, 265
Mansa Serrato, A. Marian (1995)
A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.The Journal of clinical investigation, 96 6
(1998)
DNA and i - , . : ire associated with the risk of coronary heart ~ c i c ? a
R. Hegele, J. Brunt, P. Connelly (1996)
Genetic and biochemical factors associated with variation in blood pressure in a genetic isolate.Hypertension, 27 2
J. Ruiz, A. Morabia, H. Blanché, R. James, M. Garin, G. Charpentier, P. Passa, C. Vaisse, P. Froguel (1995)
Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetesThe Lancet, 346
B. Du (1996)
Structural and functional diversity of paraoxonasesNature Medicine, 2
J. Witte, R. Elston, N. Schork (1996)
Genetic dissection of complex traitsNature Genetics, 12
We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala → Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p <0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3–22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
Clinical Genetics – Wiley
Published: Nov 1, 1998
Keywords: genetic variation; paraoxonase-2; plasma lipoprotein
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.