Genetic variants of microRNA processing genes and risk of non‐syndromic orofacial clefts

Genetic variants of microRNA processing genes and risk of non‐syndromic orofacial clefts INTRODUCTIONOrofacial clefts are major craniofacial congenital abnormalities, characterized by unsuccessful fusion of normal facial processes (Fraser, ; Mossey, Little, Munger, Dixon, & Shaw, ). Non‐syndromic orofacial clefts (NSOC), without any other major developmental accompanied abnormalities, constituted the majority of orofacial clefts (Cobourne, ). Among all the risk factors during NSOC progression, the genetic factor takes a critical role. There are three main types of orofacial clefts: cleft lip only (CLO), cleft lip with palate (CLP), and cleft palate only (CPO) (Lacheretz & Poupard, ). Depending on the similarities in both epidemiologic features and embryologic timing, CLP and CLO are traditionally grouped together to form the group cleft lip with or without cleft palate (CL/P) (Lidral, Moreno, & Bullard, ).MicroRNAs (miRNAs) are endogenous non‐coding RNAs participating in the regulation of process of life, such as proliferation and apoptosis, among other biological processes (Bentwich et al., ). MiRNAs played important roles in craniofacial development. For instance, a recent study showed that miRNA‐23b and miRNA‐133b participated in mid‐facial developmental process (Ding et al., ).Expression and synthesis of miRNAs are regulated by miRNA processing genes. Initially, primary miRNAs (pri‐miRNAs) are transcribed by RNA polymeraseII inside nucleus. DROSHA (RNAseIII) and its cofactor DGCR8 cleave pri‐miRNAs, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Diseases Wiley

Genetic variants of microRNA processing genes and risk of non‐syndromic orofacial clefts

Loading next page...
 
/lp/wiley/genetic-variants-of-microrna-processing-genes-and-risk-of-non-EpHc0RTpis
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley &Sons Ltd
ISSN
1354-523X
eISSN
1601-0825
D.O.I.
10.1111/odi.12741
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONOrofacial clefts are major craniofacial congenital abnormalities, characterized by unsuccessful fusion of normal facial processes (Fraser, ; Mossey, Little, Munger, Dixon, & Shaw, ). Non‐syndromic orofacial clefts (NSOC), without any other major developmental accompanied abnormalities, constituted the majority of orofacial clefts (Cobourne, ). Among all the risk factors during NSOC progression, the genetic factor takes a critical role. There are three main types of orofacial clefts: cleft lip only (CLO), cleft lip with palate (CLP), and cleft palate only (CPO) (Lacheretz & Poupard, ). Depending on the similarities in both epidemiologic features and embryologic timing, CLP and CLO are traditionally grouped together to form the group cleft lip with or without cleft palate (CL/P) (Lidral, Moreno, & Bullard, ).MicroRNAs (miRNAs) are endogenous non‐coding RNAs participating in the regulation of process of life, such as proliferation and apoptosis, among other biological processes (Bentwich et al., ). MiRNAs played important roles in craniofacial development. For instance, a recent study showed that miRNA‐23b and miRNA‐133b participated in mid‐facial developmental process (Ding et al., ).Expression and synthesis of miRNAs are regulated by miRNA processing genes. Initially, primary miRNAs (pri‐miRNAs) are transcribed by RNA polymeraseII inside nucleus. DROSHA (RNAseIII) and its cofactor DGCR8 cleave pri‐miRNAs, and

Journal

Oral DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off