INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone
Journal of Digestive Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ;
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