INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone
Journal of Digestive Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera