Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers

Genetic variants in the histone methylation and acetylation pathway and their risks in eight... INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Digestive Diseases Wiley

Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers

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Publisher
Wiley
Copyright
© 2018 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
ISSN
1751-2972
eISSN
1751-2980
D.O.I.
10.1111/1751-2980.12574
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Abstract

INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone

Journal

Journal of Digestive Diseases – Wiley

Published: Jan 1, 2018

Keywords: ; ;

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