Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers

Genetic variants in the histone methylation and acetylation pathway and their risks in eight... INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Digestive Diseases Wiley

Genetic variants in the histone methylation and acetylation pathway and their risks in eight types of cancers

Loading next page...
 
/lp/wiley/genetic-variants-in-the-histone-methylation-and-acetylation-pathway-BY9WwnScMg
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
ISSN
1751-2972
eISSN
1751-2980
D.O.I.
10.1111/1751-2980.12574
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe global cancer burden has continued to climb over the past decade. The development of cancer is thought to be a consequence of the accumulation of genetic alterations. Genome‐wide association studies evaluate genetic variants across the genome of different individuals to discern whether any one variant is related to a particular disease. The relation between single nucleotide polymorphisms (SNPs) and specific human diseases like cancer is a major focus of genome‐wide association studies. However, the analysis of the associations of a single site can explain only a small part of the genetic mechanism. Integrative analysis based on pathway levels can be used to investigate the cumulative relationship between a group of loci or genes and diseases.The epigenetic regulation of gene expression by histone modifications has recently been shown to be involved in cancer development. Histone methylation and acetylation are common histone modifications that play essential roles in the development of cancer. Reversible histone methylation and acetylation are important processes that are catalyzed by histone demethylases, histone methyltransferases, histone deacetylases and histone acetyltransferases. Aberrations in histone acetylation and methylation occur frequently in cancer, including changes in their distribution and levels in different genetic regions. Therefore, histone acetyltransferases, histone deacetylases, histone

Journal

Journal of Digestive DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off