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J. Todd, T. Aitman, R. Cornall, Soumitra Ghosh, J. Hall, C. Hearne, A. Knight, J. Love, M. McAleer, J. Prins, N. Rodrigues, M. Lathrop, A. Pressey, Nicole Delarato, L. Peterson, L. Wicker (1991)
Genetic analysis of autoimmune type 1 diabetes mellitus in miceNature, 351
S. Wright (1934)
The Results of Crosses between Inbred Strains of Guinea Pigs, Differing in Number of Digits.Genetics, 19 6
R. Degen, H. Degen, Christine Roth (1990)
Some Genetic Aspects of Idiopathic and Symptomatic Absence Seizures: Waking and Sleep EEGs in SiblingsEpilepsia, 31
L. Crittenden (1961)
AN INTERPRETATION OF FAMILIAL AGGREGATION BASED ON MULTIPLE GENETIC AND ENVIRONMENTAL FACTORSAnnals of the New York Academy of Sciences, 91
P Gloor, RG Fariello (1988)
Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy, 11
K. Metrakos, J. Metrakos (1960)
Genetics of convulsive disordersNeurology, 11
D. Falconer (1967)
The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitusAnnals of Human Genetics, 31
G. Micheletti, M. Vergnes, C. Marescaux, J. Reis, A. Depaulis, L. Rumbach, J. Warter (1985)
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.Arzneimittel-Forschung, 35 2
S. Maxson, Anne Didier-Erickson, Sonoko Ogawa (1989)
The Y chromosome, social signals, and offense in mice.Behavioral and neural biology, 52 2
Paul Neumann, Robert Collins (1991)
Genetic dissection of susceptibility to audiogenic seizures in inbred mice.Proceedings of the National Academy of Sciences of the United States of America, 88
G. Buzsáki, RG Bickford, G. Ponomareff, LJ Thal, R. Mandel, FH Gage (1988)
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat, 8
Gábor Jandó, Richard Siegel, Z. Horváth, György Buzsáki (1993)
Pattern recognition of the electroencephalogram by artificial neural networks.Electroencephalography and clinical neurophysiology, 86 2
T. McGuire, T. Tully (1987)
Characterization of genes involved with classical conditioning that produce differences between bidirectionally selected strains of the blow flyPhormia reginaBehavior Genetics, 17
M. Vergnes, C. Marescaux, A. Depaulis, G. Micheletti, J. Warter (1986)
Ontogeny of spontaneous petit mal-like seizures in Wistar ratsBrain Research, 395
C. Waddington (1953)
GENETIC ASSIMILATION OF AN ACQUIRED CHARACTEREvolution, 7
C. Marescaux, M. Vergnes, G. Micheletti, A. Depaulis, J. Reis, L. Rumbach, J. Warter, D. Kurtz (1984)
[A genetic form of petit mal absence in Wistar rats].Revue neurologique, 140 1
J. Hall (1990)
Genomic imprinting: review and relevance to human diseases.American journal of human genetics, 46 5
H. Jacob, K. Lindpaintner, S. Lincoln, K. Kusumi, R. Bunker, Y. Mao, D. Ganten, V. Dzau, E. Lander (1991)
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive ratCell, 67
David Fulker (1970)
Maternal buffering of rodent genotypic responses to stress: A complex genotype-environment interactionBehavior Genetics, 1
J. Holowach, D. Thurston, J. O'leary (1962)
Petit mal epilepsy.Pediatrics, 30
E Andermann (1980)
Advances in Epileptology: Xlth Epilepsy International Symposium
A. Coenen, E. Luijtelaar (1987)
The WAG/Rij rat model for absence epilepsy: age and sex factorsEpilepsy Research, 1
JH Bruell (1962)
Roots of Behavior
R. Curnow, C. Dunnett (1962)
The Numerical Evaluation of Certain Multivariate Normal IntegralsAnnals of Mathematical Statistics, 33
G. Buzsáki, I. Laszlovszky, A. Lajtha, C. Vadász (1990)
Spike-and-wave neocortical patterns in rats: Genetic and aminergic controlNeuroscience, 38
V. Ryan, F. Wehmer (1975)
Effect of postnatal litter size on adult aggression in the laboratory mouse.Developmental psychobiology, 8 4
C. Marescaux, Gabriel Micheletti, M. Vergnes, Antoine Depaulis, L. Rumbach, Jean-Marie Warter (1984)
A Model of Chronic Spontaneous Petit Mal‐like Seizures in the Rat: Comparison with Pentylenetetrazol‐Induced SeizuresEpilepsia, 25
G. Buzsáki, A. Smith, S. Berger, L. Fisher, Fred Gage, G. Aston-Jones, F. Bloom (1990)
Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemakerNeuroscience, 36
S. Wright (1934)
An Analysis of Variability in Number of Digits in an Inbred Strain of Guinea Pigs.Genetics, 19 6
M. Vergens, C. Marescaux, G. Micheletti, A. Depaulis, L. Rumbach, J. Warter (1984)
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mallike epilepsyNeuroscience Letters, 44
B. Peeters, J. Kerbusch, E. Luijtelaar, J. Vossen, A. Coenen (1990)
Genetics of absence epilepsy in ratsBehavior Genetics, 20
LL Cavalli (1952)
Quantitative Inheritance
VE Anderson, WA Hauser, JK Penry, CF Sing (1982)
Genetic Basis of the Epilepsies
A. Matthes, H. Weber (1968)
Klinische und elektroenzephalographische Familienuntersuchungen bei PyknolepsienDeutsche Medizinische Wochenschrift, 93
David Hosford, Suzanne Clark, Zhen Cao, Wilkie Wilson, F. Lin, R. Morrisett, Alexandre Huin (1992)
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.Science, 257 5068
Ruth Ottman, F. John, Annegers, W. Hauser, L. Kurland (1988)
Higher risk of seizures in offspring of mothers than of fathers with epilepsy.American journal of human genetics, 43 3
A. Robertson, Lerner Im (1949)
The Heritability of All-or-None Traits: Viability of Poultry.Genetics, 34 4
R. Curnow, Charles Smith (1975)
Multifactorial Models for Familial Diseases in Man, 138
Matthew Rise, Wayne Frankel, John Coffin, Thomas Seyfried (1991)
Genes for epilepsy mapped in the mouse.Science, 253 5020
D. Falconer (1965)
The inheritance of liability to certain diseases, estimated from the incidence among relativesAnnals of Human Genetics, 29
B. Peeters, J. Kerbusch, A. Coenen, J. Vossen, E. Luijtelaar (1992)
Genetics of spike-wave discharges in the electroencephalogram (EEG) of the WAG/Rij inbred rat strain: A classical mendelian crossbreeding studyBehavior Genetics, 22
H Gruneberg (1952)
Genetical studies on the skeleton of the mouse. IV. Quasi‐continuous variations, 51
G. Krauss, P. Kaplan, R. Fisher (1989)
Parenteral magnesium sulfate fails to control electroshock and pentylenetetrazol seizures in miceEpilepsy Research, 4
J. Noebels, R. Sidman (1979)
Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering.Science, 204 4399
DS Falconer (1981)
Introduction to Quantitative Genetics
DS Falconer (1963)
Methodology in Mammalian Genetics
M. Inoue, B. Peeters, E. Luijtelaar, J. Vossen, A. Coenen (1990)
Spontaneous occurrence of spike-wave discharges in five inbred strains of ratsPhysiology & Behavior, 48
A. Paterson, E. Lander, J. Hewitt, Susan Peterson, S. Lincoln, S. Tanksley (1988)
Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphismsNature, 335
C. Aldinio, F. Aporti, G. Calderini, S. Mazzari, A. Zanotti, G. Toffano (1985)
Experimental models of aging and quinolinic acid.Methods and findings in experimental and clinical pharmacology, 7 11
E. Dempster, I. Lerner (1950)
Heritability of Threshold Characters.Genetics, 35 2
Neocortical high‐voltage spike‐and‐wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by a simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex‐linked‐epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike‐and‐wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike‐and‐wave pattern. We propose that both genetic and developmental‐environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike‐and‐wave discharges. © 1995 Wiley‐Liss, Inc.
American Journal of Medical Genetics Part A – Wiley
Published: Mar 27, 1997
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