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Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer

Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer Decock J, Paridaens R, Ye S. Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.Clin Genet 2008: 73: 197–211. © Blackwell Munksgaard, 2008The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer

Clinical Genetics , Volume 73 (3) – Mar 1, 2008

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References (95)

Publisher
Wiley
Copyright
2007 Blackwell Munksgaard
ISSN
0009-9163
eISSN
1399-0004
DOI
10.1111/j.1399-0004.2007.00946.x
pmid
18177467
Publisher site
See Article on Publisher Site

Abstract

Decock J, Paridaens R, Ye S. Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer.Clin Genet 2008: 73: 197–211. © Blackwell Munksgaard, 2008The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer.

Journal

Clinical GeneticsWiley

Published: Mar 1, 2008

Keywords: breast cancer; colorectal cancer; lung cancer; matrix metalloproteinases; polymorphism; SNP; survival; susceptibility

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