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Genetic association study between α 1‐antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

Genetic association study between α 1‐antichymotrypsin polymorphism and Alzheimer disease in... We investigated a common signal peptide polymorphism in the α 1‐antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Han population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:133–135, 2000. © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Genetic association study between α 1‐antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
0148-7299
eISSN
1096-8628
DOI
10.1002/(SICI)1096-8628(20000403)96:2<133::AID-AJMG1>3.3.CO;2-P
Publisher site
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Abstract

We investigated a common signal peptide polymorphism in the α 1‐antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Han population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:133–135, 2000. © 2000 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics – Wiley

Published: Apr 3, 2000

Keywords: α 1‐antichymotrypsin; apolipoprotein E; Alzheimer disease

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