Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Genetic and segregation analysis of congenital cataract in the Indian population

Genetic and segregation analysis of congenital cataract in the Indian population Congenital cataract is a major cause of blindness in children, and there is wide variation in the few reports available on the frequencies of its different inheritance patterns. Two hundred and fifty-two families with congenital cataract belonging to 13 different states of India, were clinically and genetically investigated to study their inheritance and segregation patterns. Twenty-one percent of the cases were autosomal recessive, 15% autosomal dominant, 63% were simplex cases, and in the remaining cases the inheritance pattern was not clear. A high incidence of consanguinity (50.9%) was observed in autosomal recessive cases. Out of 340 affected individuals, 222 (65.3%) were males and 118 (34.7%) were females. Segregation analysis showed good agreement in autosomal dominant and recessive families and the data are indicative of the prevalence rate for different inheritance patterns of congenital cataract within the Indian population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

Genetic and segregation analysis of congenital cataract in the Indian population

Vanita, Jai Rup; Singh, Daljit; Singh, Daljit
Clinical Genetics , Volume 56 (5) – Nov 1, 1999
Download PDF
5 pages

Loading next page...
 
/lp/wiley/genetic-and-segregation-analysis-of-congenital-cataract-in-the-indian-UiUti5sanH

References (22)

Publisher
Wiley
Copyright
Munksgaard 1999
ISSN
0009-9163
eISSN
1399-0004
DOI
10.1034/j.1399-0004.1999.560507.x
Publisher site
See Article on Publisher Site

Abstract

Congenital cataract is a major cause of blindness in children, and there is wide variation in the few reports available on the frequencies of its different inheritance patterns. Two hundred and fifty-two families with congenital cataract belonging to 13 different states of India, were clinically and genetically investigated to study their inheritance and segregation patterns. Twenty-one percent of the cases were autosomal recessive, 15% autosomal dominant, 63% were simplex cases, and in the remaining cases the inheritance pattern was not clear. A high incidence of consanguinity (50.9%) was observed in autosomal recessive cases. Out of 340 affected individuals, 222 (65.3%) were males and 118 (34.7%) were females. Segregation analysis showed good agreement in autosomal dominant and recessive families and the data are indicative of the prevalence rate for different inheritance patterns of congenital cataract within the Indian population.

Journal

Clinical Genetics – Wiley

Published: Nov 1, 1999

Keywords: congenital cataract; consanguinity; inheritance; segregation analysis

There are no references for this article.