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Genes, time to first cigarette and nicotine dependence in a general population sample of young adults

Genes, time to first cigarette and nicotine dependence in a general population sample of young... ABSTRACT Aim To examine variation in nicotine dependence scores and covariation between different dependence symptoms. Design A 12‐year, nationally representative, probability‐based survey of adolescent health‐related behaviors and their outcomes during young adulthood in the United States. The genetic contribution to nicotine dependence was evaluated in the sibling‐pairs sample of the US National Longitudinal Study of Adolescent Health. Measurements Nicotine dependence (ND) was assessed using the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HSI) in 1154 young adults, between the ages of 18 and 25 years, who were from twin, full sibling and half‐sibling pairs. Findings Dependence in this sample was common and varied in degree. Total HSI scores evidenced moderate to large heritable contributions (61%, 95% confidence interval (CI): 0.46–0.72), as did the quantity of cigarettes smoked (52%, 95% CI: 0.39–0.63) and urgency to smoke (55%, 95% CI: 0.38–0.68). Multivariate modeling identified a highly heritable underlying factor (76%, 95% CI: 0.56–0.91) that influenced the covariation of dependence symptoms and loaded most heavily on how soon after waking a smoker uses his or her first cigarette. The quantity of cigarettes smoked per day also evidenced residual genetic influences that were not common to other dependence‐related behaviors. Conclusions In this sample of young adults from the general population, both genes and individual‐specific environments are important etiological factors in ND. The urgency to smoke, as measured by the time to first cigarette, may be the most informative measure on the FTND for genetic studies of nicotine dependence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Addiction Wiley

Genes, time to first cigarette and nicotine dependence in a general population sample of young adults

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Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0965-2140
eISSN
1360-0443
DOI
10.1111/j.1360-0443.2007.01746.x
pmid
17309537
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Aim To examine variation in nicotine dependence scores and covariation between different dependence symptoms. Design A 12‐year, nationally representative, probability‐based survey of adolescent health‐related behaviors and their outcomes during young adulthood in the United States. The genetic contribution to nicotine dependence was evaluated in the sibling‐pairs sample of the US National Longitudinal Study of Adolescent Health. Measurements Nicotine dependence (ND) was assessed using the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HSI) in 1154 young adults, between the ages of 18 and 25 years, who were from twin, full sibling and half‐sibling pairs. Findings Dependence in this sample was common and varied in degree. Total HSI scores evidenced moderate to large heritable contributions (61%, 95% confidence interval (CI): 0.46–0.72), as did the quantity of cigarettes smoked (52%, 95% CI: 0.39–0.63) and urgency to smoke (55%, 95% CI: 0.38–0.68). Multivariate modeling identified a highly heritable underlying factor (76%, 95% CI: 0.56–0.91) that influenced the covariation of dependence symptoms and loaded most heavily on how soon after waking a smoker uses his or her first cigarette. The quantity of cigarettes smoked per day also evidenced residual genetic influences that were not common to other dependence‐related behaviors. Conclusions In this sample of young adults from the general population, both genes and individual‐specific environments are important etiological factors in ND. The urgency to smoke, as measured by the time to first cigarette, may be the most informative measure on the FTND for genetic studies of nicotine dependence.

Journal

Addiction – Wiley

Published: Apr 1, 2007

References

  • Epidemiology of tobacco use in the United States
    Giovino, Giovino
  • US college students' use of tobacco products
    Rigotti, Rigotti; Lee, Lee; Wechsler, Wechsler
  • Tobacco use among middle and high school students—United States, 2002
    Allen, Allen; Vallone, Vallone; Haviland, Haviland; Healton, Healton; Davis, Davis; Farrelly, Farrelly
  • Nicotine dependence in the United States: prevalence, trends, and smoking persistence
    Breslau, Breslau; Johnson, Johnson; Hiripi, Hiripi; Kessler, Kessler
  • Actual causes of death in the United States 2000
    Mokdad, Mokdad; Marks, Marks; Stroup, Stroup; Gerberding, Gerberding
  • From neurobiology to treatment: progress against addiction
    Nestler, Nestler
  • Addiction and the brain. the neurobiology of compulsion and its persistence
    Hyman, Hyman; Malenka, Malenka
  • The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
    Heatherton, Heatherton; Kozlowski, Kozlowski; Frecker, Frecker; Fagerstrom, Fagerstrom
  • Measuring the heaviness of smoking: using self‐reported time to the first cigarette of the day and number of cigarettes per day
    Heatherton, Heatherton; Kozlowski, Kozlowski; Frecker, Frecker; Rickert, Rickert; Robinson, Robinson
  • Validity of the Fagerström test for nicotine dependence and the heaviness of smoking index among relatively light smokers
    Etter, Etter; Duc, Duc; Perneger, Perneger
  • Predicting smoking cessation with self‐reported measures of nicotine dependence. FTQ, FTND, and HSI
    Kozlowski, Kozlowski; Porter, Porter; Orleans, Orleans; Pope, Pope; Heatherton, Heatherton
  • Is the FTND a measure of physical as well as psychological tobacco dependence?
    Dijkstra, Dijkstra; Tromp, Tromp
  • A study of the psychometric and predictive properties of the Fagerstrom Test for Nicotine Dependence in a population of young smokers
    Haddock, Haddock; Lando, Lando; Klesges, Klesges; Talcott, Talcott; Renaud, Renaud
  • A confirmatory factor analysis of the Fagerstrom Test for Nicotine Dependence
    Richardson, Richardson; Ratner, Ratner
  • A factor analysis of the Fagerstrom Test for Nicotine Dependence (FTND)
    Radzius, Radzius; Gallo, Gallo; Epstein, Epstein; Gorelick, Gorelick; Cadet, Cadet; Uhl, Uhl
  • Pharmacotherapy and pharmacogenetics of nicotine dependence
    Berrettini, Berrettini; Lerman, Lerman
  • Nicotine dose predicts using time to first cigarette
    Fagerstrom, Fagerstrom
  • Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
    Marks, Marks; Pauly, Pauly; Gross, Gross; Dneris, Dneris; Hermans‐Borgmeyer, Hermans‐Borgmeyer; Heinemann, Heinemann
  • The genetic epidemiology of smoking
    Sullivan, Sullivan; Kendler, Kendler
  • A meta‐analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    Li, Li; Cheng, Cheng; Ma, Ma; Swan, Swan
  • Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: univariate and multivariate behavioral genetic analyses
    Han, Han; McGue, McGue; Iacono, Iacono
  • Tobacco consumption in Swedish twins reared apart and reared together
    Kendler, Kendler; Thornton, Thornton; Pederson, Pederson
  • A population‐based twin study in women of smoking initiation and nicotine dependence
    Kendler, Kendler; Neale, Neale; Sullivan, Sullivan; Corey, Corey; Gardner, Gardner; Prescott, Prescott
  • The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins
    Koopmans, Koopmans; Slutske, Slutske; Heath, Heath; Neale, Neale; Boomsma, Boomsma
  • Defining nicotine dependence for genetic research: evidence from Australian twins
    Lessov, Lessov; Martin, Martin; Statham, Statham; Todorov, Todorov; Slutske, Slutske; Bucholz, Bucholz
  • Heritability of smoking initiation and nicotine dependence
    Vink, Vink; Willemsen, Willemsen; Boomsma, Boomsma
  • A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Maes, Maes; Sullivan, Sullivan; Bulik, Bulik; Neale, Neale; Prescott, Prescott; Eaves, Eaves
  • Common genetic vulnerability for nicotine dependence and alcohol dependence in men
    True, True; Xian, Xian; Scherrer, Scherrer; Madden, Madden; Bucholz, Bucholz; Heath, Heath
  • Measuring nicotine dependence among youth: a review of the available approaches and instruments
    Colby, Colby; Tiffany, Tiffany; Shiffman, Shiffman; Niaura, Niaura
  • Validity of retrospective assessments of nicotine dependence: a preliminary report
    Hudmon, Hudmon; Pomerleau, Pomerleau; Brigham, Brigham; Javitz, Javitz; Swan, Swan
  • Factor analyses and AIC
    Akaike, Akaike
  • Exploring brief measures of nicotine dependence for epidemiological surveys
    De Leon, De Leon; Diaz, Diaz; Becona, Becona; Gurpegui, Gurpegui; Jurado, Jurado; Gonzalez‐Pinto, Gonzalez‐Pinto
  • Molecular and cellular aspects of nicotine abuse
    Dani, Dani; Heinemann, Heinemann
  • Nicotine addiction: the possible role of functional upregulation
    Buisson, Buisson; Bertrand, Bertrand
  • Allosteric modulation of ligand‐gated ion channels
    Hogg, Hogg; Buisson, Buisson; Bertrand, Bertrand
  • Efficacy of a nicotine lozenge for smoking cessation
    Shiffman, Shiffman; Dresler, Dresler; Hajek, Hajek; Gilburt, Gilburt; Targett, Targett; Strahs, Strahs
  • Linkage analysis of smoking initiation and quantity in Dutch sibling pairs
    Vink, Vink; Beem, Beem; Posthuma, Posthuma; Neale, Neale; Willemsen, Willemsen; Kendler, Kendler
  • Results for a genomewide scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
    Gelernter, Gelernter; Liu, Liu; Hesselbrock, Hesselbrock; Page, Page; Goddard, Goddard; Zhang, Zhang
  • A genome‐wide scan to identify loci for smoking rate in the Framingham Heart Study population
    Li, Li; Ma, Ma; Cheng, Cheng; Dupont, Dupont; Williams, Williams; Crews, Crews
  • Concordance of different measures of nicotine dependence: Two pilot studies
    Hughes, Hughes; Oliveto, Oliveto; Riggs, Riggs; Kenny, Kenny; Ligouri, Ligouri; Pillitteri, Pillitteri
  • The Fagerstrom test for nicotine dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?
    Moolchan, Moolchan; Radzius, Radzius; Epstein, Epstein; Uhl, Uhl; Gorelick, Gorelick; Cadet, Cadet

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