Genes, time to first cigarette and nicotine dependence in a general population sample of young adults

Genes, time to first cigarette and nicotine dependence in a general population sample of young... ABSTRACT Aim To examine variation in nicotine dependence scores and covariation between different dependence symptoms. Design A 12‐year, nationally representative, probability‐based survey of adolescent health‐related behaviors and their outcomes during young adulthood in the United States. The genetic contribution to nicotine dependence was evaluated in the sibling‐pairs sample of the US National Longitudinal Study of Adolescent Health. Measurements Nicotine dependence (ND) was assessed using the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HSI) in 1154 young adults, between the ages of 18 and 25 years, who were from twin, full sibling and half‐sibling pairs. Findings Dependence in this sample was common and varied in degree. Total HSI scores evidenced moderate to large heritable contributions (61%, 95% confidence interval (CI): 0.46–0.72), as did the quantity of cigarettes smoked (52%, 95% CI: 0.39–0.63) and urgency to smoke (55%, 95% CI: 0.38–0.68). Multivariate modeling identified a highly heritable underlying factor (76%, 95% CI: 0.56–0.91) that influenced the covariation of dependence symptoms and loaded most heavily on how soon after waking a smoker uses his or her first cigarette. The quantity of cigarettes smoked per day also evidenced residual genetic influences that were not common to other dependence‐related behaviors. Conclusions In this sample of young adults from the general population, both genes and individual‐specific environments are important etiological factors in ND. The urgency to smoke, as measured by the time to first cigarette, may be the most informative measure on the FTND for genetic studies of nicotine dependence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Addiction Wiley

Genes, time to first cigarette and nicotine dependence in a general population sample of young adults

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Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0965-2140
eISSN
1360-0443
DOI
10.1111/j.1360-0443.2007.01746.x
pmid
17309537
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Aim To examine variation in nicotine dependence scores and covariation between different dependence symptoms. Design A 12‐year, nationally representative, probability‐based survey of adolescent health‐related behaviors and their outcomes during young adulthood in the United States. The genetic contribution to nicotine dependence was evaluated in the sibling‐pairs sample of the US National Longitudinal Study of Adolescent Health. Measurements Nicotine dependence (ND) was assessed using the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HSI) in 1154 young adults, between the ages of 18 and 25 years, who were from twin, full sibling and half‐sibling pairs. Findings Dependence in this sample was common and varied in degree. Total HSI scores evidenced moderate to large heritable contributions (61%, 95% confidence interval (CI): 0.46–0.72), as did the quantity of cigarettes smoked (52%, 95% CI: 0.39–0.63) and urgency to smoke (55%, 95% CI: 0.38–0.68). Multivariate modeling identified a highly heritable underlying factor (76%, 95% CI: 0.56–0.91) that influenced the covariation of dependence symptoms and loaded most heavily on how soon after waking a smoker uses his or her first cigarette. The quantity of cigarettes smoked per day also evidenced residual genetic influences that were not common to other dependence‐related behaviors. Conclusions In this sample of young adults from the general population, both genes and individual‐specific environments are important etiological factors in ND. The urgency to smoke, as measured by the time to first cigarette, may be the most informative measure on the FTND for genetic studies of nicotine dependence.

Journal

AddictionWiley

Published: Apr 1, 2007

References

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