We have read with great interest the report by Wiles et al, published in Cancer Cytopathology, about the immunohistochemical expression of the GATA3 antibody in cytological material from neuroblastomas. They evaluated GATA3 immunohistochemical expression in neuroblastoma cytology and/or biopsy samples, and diffuse nuclear positivity was found in all 30 specimens studied. Each sample revealed either strong (n = 26) or moderate nuclear staining (n = 4) in more than 75% of neuroblastoma cells, regardless of the presence or lack of stromata, necrosis, or differentiation.GATA3 is a relatively recent marker useful for diagnosing tumors of various epithelial and nonepithelial origins such as mammary tumors, urothelial tumors, renal tumors, germ cell tumors, mesotheliomas, and paragangliomas. Moreover, it is usually negative in round cell sarcomas. In contrast, little is known about GATA3 expression in blastemal or other small round cell pediatric tumors. Nonaka et al reported the presence of diffuse GATA3 expression in the neuroblastoma family of tumors and a lack of expression in other small round cell tumors.The distinction between neuroblastomas and nephroblastomas may be delicate because the clinical and radiological presentation may be overlapping. Moreover, we have previously encountered important difficulties in the cytological differential diagnosis between poorly differentiated neuroblastomas
Cancer Cytopathology – Wiley
Published: Jan 1, 2018
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