Functional Properties of Stored Red Cells

Functional Properties of Stored Red Cells DE VERDIER Department of Clinical Chemistry, University Hospital, Uppsala During the last two decades many efforts have been made to improve storage conditions for erythrocytes. This has resulted in prolonged storage time and higher erythrocyte viability after transfusion. A great number of biochemical parameters has been studied but, except for viability, the functional adequacy of the product has not until recently been investigated. If the relations between function and biochemical parameters were well known, it would be sufficient and in many cases simpler t o make the biochemical studies only. Little is known, however, and these questions will be dealt with after a brief presentation of the biochemical changes taking place during storage. I will restrict this introduction and only discuss two procedures for preservation, e.g. ACD- or supplemented ACD-solutions for storage a t +4"C and low glycerol - liquid nitrogen systems for storage at -196°C. When an erythrocyte is stored in ACD-solution, the conditions for the erythrocyte is changed as indicated in figure 1,e.g. with respect t o temperature and the concentration of glucose, hydrogen ion, lactate and adenine. These conditional changes will impose biochemical changes, some of which will be irreversible in the sense that the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vox Sanguinis Wiley

Functional Properties of Stored Red Cells

Vox Sanguinis, Volume 16 (5) – May 1, 1969

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Publisher
Wiley
Copyright
© 1969 Blackwell Publishing Ltd
ISSN
0042-9007
eISSN
1423-0410
DOI
10.1111/j.1423-0410.1969.tb04763.x
Publisher site
See Article on Publisher Site

Abstract

DE VERDIER Department of Clinical Chemistry, University Hospital, Uppsala During the last two decades many efforts have been made to improve storage conditions for erythrocytes. This has resulted in prolonged storage time and higher erythrocyte viability after transfusion. A great number of biochemical parameters has been studied but, except for viability, the functional adequacy of the product has not until recently been investigated. If the relations between function and biochemical parameters were well known, it would be sufficient and in many cases simpler t o make the biochemical studies only. Little is known, however, and these questions will be dealt with after a brief presentation of the biochemical changes taking place during storage. I will restrict this introduction and only discuss two procedures for preservation, e.g. ACD- or supplemented ACD-solutions for storage a t +4"C and low glycerol - liquid nitrogen systems for storage at -196°C. When an erythrocyte is stored in ACD-solution, the conditions for the erythrocyte is changed as indicated in figure 1,e.g. with respect t o temperature and the concentration of glucose, hydrogen ion, lactate and adenine. These conditional changes will impose biochemical changes, some of which will be irreversible in the sense that the

Journal

Vox SanguinisWiley

Published: May 1, 1969

References

  • Glycerol treated human red cells frozen with liquid nitrogen
    Krijnen, Krijnen; Wit, Wit; Kuivenhoven, Kuivenhoven; Loos, Loos; Prins, Prins
  • Further studies on the effect of adenine in blood preservation
    Åkerblom, Åkerblom; Verdier, Verdier; Finnson, Finnson; Garby, Garby; Högman, Högman; Johansson, Johansson
  • The viability of human blood stored in phosphate adenine media
    Wood, Wood; Beutler, Beutler

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