DE VERDIER Department of Clinical Chemistry, University Hospital, Uppsala During the last two decades many efforts have been made to improve storage conditions for erythrocytes. This has resulted in prolonged storage time and higher erythrocyte viability after transfusion. A great number of biochemical parameters has been studied but, except for viability, the functional adequacy of the product has not until recently been investigated. If the relations between function and biochemical parameters were well known, it would be sufficient and in many cases simpler t o make the biochemical studies only. Little is known, however, and these questions will be dealt with after a brief presentation of the biochemical changes taking place during storage. I will restrict this introduction and only discuss two procedures for preservation, e.g. ACD- or supplemented ACD-solutions for storage a t +4"C and low glycerol - liquid nitrogen systems for storage at -196Â°C. When an erythrocyte is stored in ACD-solution, the conditions for the erythrocyte is changed as indicated in figure 1,e.g. with respect t o temperature and the concentration of glucose, hydrogen ion, lactate and adenine. These conditional changes will impose biochemical changes, some of which will be irreversible in the sense that the
Vox Sanguinis – Wiley
Published: May 1, 1969
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