Fulminant Cryptococcus neoformans infection with fatal pericardial tamponade in a patient with chronic myelomonocytic leukaemia who was treated with ruxolitinib: Case report and review of fungal pericarditis

Fulminant Cryptococcus neoformans infection with fatal pericardial tamponade in a patient with... Cryptococcus neoformans is a saprophytic fungal pathogen that can cause serious illness in immune‐compromised hosts and it presents with a wide variety of clinical symptoms. We present a fatal case of fulminant C. neoformans infection presenting as pericardial tamponade in a 71‐year‐old male with chronic myelomonocytic leukaemia undergoing chemotherapy with the JAK‐STAT inhibitor ruxolitinib. We also review the published cases of fungal pericarditis/tamponade. In addition to illustrating an atypical presentation of C. neoformans, this case highlights the risk for opportunistic fungal infections in patients with haematological malignancies, especially the ones treated with small molecule kinase inhibitors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mycoses Wiley

Fulminant Cryptococcus neoformans infection with fatal pericardial tamponade in a patient with chronic myelomonocytic leukaemia who was treated with ruxolitinib: Case report and review of fungal pericarditis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Blackwell Verlag GmbH
ISSN
0933-7407
eISSN
1439-0507
D.O.I.
10.1111/myc.12735
Publisher site
See Article on Publisher Site

Abstract

Cryptococcus neoformans is a saprophytic fungal pathogen that can cause serious illness in immune‐compromised hosts and it presents with a wide variety of clinical symptoms. We present a fatal case of fulminant C. neoformans infection presenting as pericardial tamponade in a 71‐year‐old male with chronic myelomonocytic leukaemia undergoing chemotherapy with the JAK‐STAT inhibitor ruxolitinib. We also review the published cases of fungal pericarditis/tamponade. In addition to illustrating an atypical presentation of C. neoformans, this case highlights the risk for opportunistic fungal infections in patients with haematological malignancies, especially the ones treated with small molecule kinase inhibitors.

Journal

MycosesWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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