Four putative subtypes of human parvovirus B19 based on amino acid polymorphism in the C‐terminal region of non‐structural protein

Four putative subtypes of human parvovirus B19 based on amino acid polymorphism in the... The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509–4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorphism of the amino acids was seen in about 110 bases near the carboxy terminal of the non‐structural protein, ranging from nt. 2011 to 2123, where four amino acid mutation points were found to exist. Based on the amino acid polymorphism of these four mutation sites in this area, 10 isolates of the B19 parvovirus could be divided into 4 subtypes (subtypes A, B, C, and D). The frequency of isolation of the subtypes depended on the time and location of collection of the B19 viremic blood specimens. J. Med. Virol. 62:60–69, 2000. © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Four putative subtypes of human parvovirus B19 based on amino acid polymorphism in the C‐terminal region of non‐structural protein

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/1096-9071(200009)62:1<60::AID-JMV10>3.0.CO;2-X
Publisher site
See Article on Publisher Site

Abstract

The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509–4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorphism of the amino acids was seen in about 110 bases near the carboxy terminal of the non‐structural protein, ranging from nt. 2011 to 2123, where four amino acid mutation points were found to exist. Based on the amino acid polymorphism of these four mutation sites in this area, 10 isolates of the B19 parvovirus could be divided into 4 subtypes (subtypes A, B, C, and D). The frequency of isolation of the subtypes depended on the time and location of collection of the B19 viremic blood specimens. J. Med. Virol. 62:60–69, 2000. © 2000 Wiley‐Liss, Inc.

Journal

Journal of Medical VirologyWiley

Published: Sep 1, 2000

References

  • Diagnosis of human parvovirus infection by dot‐hybridization using cloned viral DNA
    Anderson, Anderson; Jones, Jones; Minson, Minson
  • Genetic diversity in the non‐structural gene of parvovirus B19 detected by single‐stranded conformational polymorphism assay (SSCP) and partial nucleotide sequencing
    Kerr, Kerr; Curran, Curran; Moore, Moore; Erdman, Erdman; Coyle, Coyle; Nunoue, Nunoue; Middleton, Middleton; Ferguson, Ferguson

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