Fos‐Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons

Fos‐Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With... Administration of convulsant drugs causes the rapid induction of c‐fos in identified neurons within the mouse central nervous system (Morgan et al., 1987). In particular, Fos‐like immunoreactivity is evident in nuclei of granule cells of the hippocampal dentate gyrus within 30 minutes of the onset of seizure. By immunoelectron microscopy, Fos antibody binding was exclusively localized to dispersed chromatin (euchromatin) of several types of projection neurons and local circuit neurons in various brain regions and especially in the dentate gyrus, 210 minutes after a single injection of Metrazol. Fos‐like immunoreactivity was not detectable in the nucleolus, nor in the characteristic peripheral and nucleolus‐associated heterochromatin of hippocampal granule cells. No immunostaining was observed in nuclei of glial, ependymal or endothelial cells, and no cytoplasmic reactivity was seen in any cell type. These findings support a role for Fos in stimulus‐response coupling at the level of transcriptional regulation in neurons. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

Fos‐Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons

Loading next page...
 
/lp/wiley/fos-like-immunoreactivity-induced-by-seizure-in-mice-is-specifically-1zc6Gz6DCT
Publisher site
See Article on Publisher Site

Abstract

Administration of convulsant drugs causes the rapid induction of c‐fos in identified neurons within the mouse central nervous system (Morgan et al., 1987). In particular, Fos‐like immunoreactivity is evident in nuclei of granule cells of the hippocampal dentate gyrus within 30 minutes of the onset of seizure. By immunoelectron microscopy, Fos antibody binding was exclusively localized to dispersed chromatin (euchromatin) of several types of projection neurons and local circuit neurons in various brain regions and especially in the dentate gyrus, 210 minutes after a single injection of Metrazol. Fos‐like immunoreactivity was not detectable in the nucleolus, nor in the characteristic peripheral and nucleolus‐associated heterochromatin of hippocampal granule cells. No immunostaining was observed in nuclei of glial, ependymal or endothelial cells, and no cytoplasmic reactivity was seen in any cell type. These findings support a role for Fos in stimulus‐response coupling at the level of transcriptional regulation in neurons.

Journal

European Journal of NeuroscienceWiley

Published: Jan 1, 1989

References

  • Memories of Fos.
    Curran, Curran; Morgan, Morgan

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off