FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals

FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to... Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain–hindbrain and midbrain‐specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell‐adhesion molecules at the midbrain–hindbrain border. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals

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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1093/emboj/cdg169
Publisher site
See Article on Publisher Site

Abstract

Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain–hindbrain and midbrain‐specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell‐adhesion molecules at the midbrain–hindbrain border.

Journal

The EMBO JournalWiley

Published: Mar 15, 2004

Keywords: ; ; ; ; ;

References

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    Danielian, PS; Muccino, D; Rowitch, DH; Michael, SK; McMahon, AP
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    Jungbluth, S; Larsen, C; Wizenmann, A; Lumsden, A
  • Expression of a novel type of classic cadherin, PB‐cadherin in developing brain and limb buds
    Kitajima, K; Koshimizu, U; Nakamura, T
  • Turn‐off, drop‐out: functional state switching of cadherins
    Lilien, J; Balsamo, J; Arregui, C; Xu, G
  • Z/AP, a double reporter for cre‐mediated recombination
    Lobe, CG; Koop, KE; Kreppner, W; Lomeli, H; Gertsenstein, M; Nagy, A
  • The prosencephalon has the capacity to differentiate into optic tectum: analysis in quail‐chick‐chimeric brains
    Nakamura, H; Takagi, S; Tsuji, T; Matsui, KA; Fujisawa, H

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