Pathogen reduction (PR) is a novel approach to decreasing pathogen transmission by blood transfusion. It has the potential to inactivate a broad range of pathogens that could be found in donated blood products and thus it would complement existing methods to prevent or decrease the presence of pathogens. The current methods include donor selection, skin disinfection, diversion of initial collection, and testing for specific agents. The concept of PR holds great promise. Ideally, PR methods should inactivate all pathogens found in blood products, not damage the transfusion product, and be safe to be administered to all patients. In reality, PR methodology is in its infancy and has yet to reach its true potential. In their current form, PR treatments are unlikely to sterilize the transfusion product. This results from large loads of certain pathogens that could overwhelm the capacity of the treatment, resistant forms of pathogens, inaccessible pathogens due to interference from storage bag geometry, poor light energy delivery due to interfering substances, and the potential for human error during processing. The PR methods are not strictly pathogen specific and produce collateral damage to the transfusion products that is often evident by the decreased retention of these products
Transfusion – Wiley
Published: Oct 1, 2003
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