INTRODUCTIONCriminal behavior (CB), Alcohol Use Disorder (AUD), and Drug Abuse (DA) are all strongly transmitted within families (Besemer, ; Cotton, ; Merikangas et al., ). Twin and adoption studies suggest that while a substantial proportion of this transmission of these syndromes results from genetic factors, familial environmental effects also contribute (Kendler et al., , ; Kendler, Ji, et al., ; Kendler, Lonn, et al., ; Verhulst, Neale, & Kendler, ). A limitation of the systematic studies of the familial transmission of AUD and DA is that they have almost exclusively examined only nuclear families—looking at resemblance of twins or siblings, or more rarely parents and children. Only with CB is there a substantial literature exploring the transmission across three generations (Besemer, ; Besemer, Axelsson, Sarnecki, ; Junger, Greene, Schipper, Hesper, & Estourgie, ; Putkonen, Ryynanen, Eronen, & Tiihonen, ; van de Weijer, Bijleveld, & Blokland, ). Avuncular relationships—between uncles/aunts and their nieces and nephews—have been even more infrequently examined because such data is rarely available.In this paper, we report a national Swedish study of transmission of the three major externalizing syndromes of CB, AUD, and DA from grandparents, aunts/uncles and parents to offspring, whom we term probands. We address
American Journal of Medical Genetics – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ; ;
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