Familial transmission of externalizing syndromes in extended Swedish families

Familial transmission of externalizing syndromes in extended Swedish families INTRODUCTIONCriminal behavior (CB), Alcohol Use Disorder (AUD), and Drug Abuse (DA) are all strongly transmitted within families (Besemer, ; Cotton, ; Merikangas et al., ). Twin and adoption studies suggest that while a substantial proportion of this transmission of these syndromes results from genetic factors, familial environmental effects also contribute (Kendler et al., , ; Kendler, Ji, et al., ; Kendler, Lonn, et al., ; Verhulst, Neale, & Kendler, ). A limitation of the systematic studies of the familial transmission of AUD and DA is that they have almost exclusively examined only nuclear families—looking at resemblance of twins or siblings, or more rarely parents and children. Only with CB is there a substantial literature exploring the transmission across three generations (Besemer, ; Besemer, Axelsson, Sarnecki, ; Junger, Greene, Schipper, Hesper, & Estourgie, ; Putkonen, Ryynanen, Eronen, & Tiihonen, ; van de Weijer, Bijleveld, & Blokland, ). Avuncular relationships—between uncles/aunts and their nieces and nephews—have been even more infrequently examined because such data is rarely available.In this paper, we report a national Swedish study of transmission of the three major externalizing syndromes of CB, AUD, and DA from grandparents, aunts/uncles and parents to offspring, whom we term probands. We address http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Familial transmission of externalizing syndromes in extended Swedish families

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Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1552-4841
eISSN
1552-485X
D.O.I.
10.1002/ajmg.b.32611
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCriminal behavior (CB), Alcohol Use Disorder (AUD), and Drug Abuse (DA) are all strongly transmitted within families (Besemer, ; Cotton, ; Merikangas et al., ). Twin and adoption studies suggest that while a substantial proportion of this transmission of these syndromes results from genetic factors, familial environmental effects also contribute (Kendler et al., , ; Kendler, Ji, et al., ; Kendler, Lonn, et al., ; Verhulst, Neale, & Kendler, ). A limitation of the systematic studies of the familial transmission of AUD and DA is that they have almost exclusively examined only nuclear families—looking at resemblance of twins or siblings, or more rarely parents and children. Only with CB is there a substantial literature exploring the transmission across three generations (Besemer, ; Besemer, Axelsson, Sarnecki, ; Junger, Greene, Schipper, Hesper, & Estourgie, ; Putkonen, Ryynanen, Eronen, & Tiihonen, ; van de Weijer, Bijleveld, & Blokland, ). Avuncular relationships—between uncles/aunts and their nieces and nephews—have been even more infrequently examined because such data is rarely available.In this paper, we report a national Swedish study of transmission of the three major externalizing syndromes of CB, AUD, and DA from grandparents, aunts/uncles and parents to offspring, whom we term probands. We address

Journal

American Journal of Medical GeneticsWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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