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Familial Mediterranean fever in two Bedouin families: Mutation analysis and disease severity

Familial Mediterranean fever in two Bedouin families: Mutation analysis and disease severity Familial Mediterranean fever (FMF) is an autosomal recessive disease prevalent among non‐Ashkenazi Jews, Armenians, Arabs, and Turks. The Bedouin are nomad Arab tribes residing in desert margins of the Middle East and Arabia. FMF is quite rare in Bedouins, and here we report on two Bedouin families from southern Israel suffering from this disorder. The MEFV mutations found in the Bedouin patients M694I, V726A, and E148Q are consistent with their Arab origin. The disease severity score showed a mild to moderate severity disease in six patients. The Bedouins, leading a unique nomadic life, may prove instrumental in unraveling the role of environmental factors in the course and severity of FMF. Am. J. Med. Genet. 92:247–249, 2000. © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Familial Mediterranean fever in two Bedouin families: Mutation analysis and disease severity

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
1552-4868
eISSN
1552-4833
DOI
10.1002/(SICI)1096-8628(20000605)92:4<247::AID-AJMG4>3.3.CO;2-Z
Publisher site
See Article on Publisher Site

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease prevalent among non‐Ashkenazi Jews, Armenians, Arabs, and Turks. The Bedouin are nomad Arab tribes residing in desert margins of the Middle East and Arabia. FMF is quite rare in Bedouins, and here we report on two Bedouin families from southern Israel suffering from this disorder. The MEFV mutations found in the Bedouin patients M694I, V726A, and E148Q are consistent with their Arab origin. The disease severity score showed a mild to moderate severity disease in six patients. The Bedouins, leading a unique nomadic life, may prove instrumental in unraveling the role of environmental factors in the course and severity of FMF. Am. J. Med. Genet. 92:247–249, 2000. © 2000 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics – Wiley

Published: Jun 5, 2000

Keywords: Bedouins; FMF; MEFV ; mutation analysis

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