Factors affecting the development of testis‐ova in medaka, Oryzias latipes , exposed to octylphenol

Factors affecting the development of testis‐ova in medaka, Oryzias latipes , exposed to... There are many endocrine‐disrupting chemicals in the environment that have the potential to alter the development of sexual characteristics in fish and wildlife. Little is known about the factors that influence the development of an intersex condition in fish. Japanese medaka (Oryzias latipes) were exposed to octylphenol (OP), a known estrogen agonist, during various life history stages to determine the factors that control induction of testis‐ova, an intersex condition. In male medaka exposed to OP (100 μg/L) beginning at 1, 3, 7, 21, and 35 d posthatch, the incidence of testis‐ova at 100 d posthatch was highest in the 3‐d posthatch treatment (4 of 14 males) and declined when exposures were initiated with older fry. Exposure to OP (100 μg/L) from hatch for a period of 1 or 2 months did not induce testis‐ova, but exposure for 3 months resulted in 3 of 50 males developing this condition. Exposures of adult male medaka to OP (200 and 300 μg/L) for either 18 or 36 d resulted in only one testis‐ova in a male fish exposed for 36 d to the highest nominal concentration. In addition to testis‐ova, male medaka exposed to OP developed testicular fibrosis. Overall, these data indicate that prolonged exposure of male medaka to an estrogen agonist beginning around the period of gonadal differentiation is optimal for the development of testis‐ova, but this intersex condition can be induced when exposure begins at later life stages. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Toxicology & Chemistry Wiley

Factors affecting the development of testis‐ova in medaka, Oryzias latipes , exposed to octylphenol

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Publisher
Wiley
Copyright
Copyright © 1999 SETAC
ISSN
0730-7268
eISSN
1552-8618
DOI
10.1002/etc.5620180834
Publisher site
See Article on Publisher Site

Abstract

There are many endocrine‐disrupting chemicals in the environment that have the potential to alter the development of sexual characteristics in fish and wildlife. Little is known about the factors that influence the development of an intersex condition in fish. Japanese medaka (Oryzias latipes) were exposed to octylphenol (OP), a known estrogen agonist, during various life history stages to determine the factors that control induction of testis‐ova, an intersex condition. In male medaka exposed to OP (100 μg/L) beginning at 1, 3, 7, 21, and 35 d posthatch, the incidence of testis‐ova at 100 d posthatch was highest in the 3‐d posthatch treatment (4 of 14 males) and declined when exposures were initiated with older fry. Exposure to OP (100 μg/L) from hatch for a period of 1 or 2 months did not induce testis‐ova, but exposure for 3 months resulted in 3 of 50 males developing this condition. Exposures of adult male medaka to OP (200 and 300 μg/L) for either 18 or 36 d resulted in only one testis‐ova in a male fish exposed for 36 d to the highest nominal concentration. In addition to testis‐ova, male medaka exposed to OP developed testicular fibrosis. Overall, these data indicate that prolonged exposure of male medaka to an estrogen agonist beginning around the period of gonadal differentiation is optimal for the development of testis‐ova, but this intersex condition can be induced when exposure begins at later life stages.

Journal

Environmental Toxicology & ChemistryWiley

Published: Aug 1, 1999

References

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