Extrahepatic complement biosynthesis: where, when and why?

Extrahepatic complement biosynthesis: where, when and why? B. P. MORGAN & P. GASQUE Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK (Accepted for publication 2 September 1996) INTRODUCTION The complement (C) system is a key component of innate immunity, playing a central role in defence against microorganisms and in the processing of immune complexes. It is also a powerful drive to inflammation and can, if unregulated, cause pathology. The last few years have seen a gradual realization that these events occur not only in the plasma, with its abundance of C proteins, but also in the tissues, where plasma C may penetrate poorly or not at all. The need for a functioning C system at these tissue sites must be met, either by increased influx of plasma C or by local synthesis. The purpose of this brief review is to summarize the evidence that C synthesis occurs at tissue sites and to advance the concept, suggested by studies in a variety of tissues, that local production of C is important in tissue homeostasis and immune defence. SOURCES OF PLASMA C Components of the classical (C1, C4, C2, C3), alternative (factor B, factor D, properdin, C3) and terminal (C5, C6, C7, C8 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Immunology Wiley

Extrahepatic complement biosynthesis: where, when and why?

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Publisher
Wiley
Copyright
Blackwell Science Ltd, Oxford
ISSN
0009-9104
eISSN
1365-2249
D.O.I.
10.1046/j.1365-2249.1997.d01-890.x
Publisher site
See Article on Publisher Site

Abstract

B. P. MORGAN & P. GASQUE Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK (Accepted for publication 2 September 1996) INTRODUCTION The complement (C) system is a key component of innate immunity, playing a central role in defence against microorganisms and in the processing of immune complexes. It is also a powerful drive to inflammation and can, if unregulated, cause pathology. The last few years have seen a gradual realization that these events occur not only in the plasma, with its abundance of C proteins, but also in the tissues, where plasma C may penetrate poorly or not at all. The need for a functioning C system at these tissue sites must be met, either by increased influx of plasma C or by local synthesis. The purpose of this brief review is to summarize the evidence that C synthesis occurs at tissue sites and to advance the concept, suggested by studies in a variety of tissues, that local production of C is important in tissue homeostasis and immune defence. SOURCES OF PLASMA C Components of the classical (C1, C4, C2, C3), alternative (factor B, factor D, properdin, C3) and terminal (C5, C6, C7, C8

Journal

Clinical & Experimental ImmunologyWiley

Published: Jan 1, 1997

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