AbbreviationsBMPbone morphogenetic proteinECMExtracellular matrixEGFepidermal growth factorFGFfibroblast growth factorMMPsmatrix metalloproteinaseTIMPsmetalloproteinase tissue specific inhibitorsTGF‐βtransforming growth factor‐βTGF‐βtransforming growth factor‐β receptorIntroductionDiabetic gastroenteropathy is a highly heterogeneous and often an unpredictable diabetic complication. Its multiple symptoms as gastroesophageal reflux, dyspepsia, abdominal pain, diarrhea, constipation or fecal incontinence, affect more than 75% of patients, with a profound impact on their quality of life (Camilleri, ; Shakil et al., ).While at present the identification of the diabetic bowel dysfunction are common due to the accessible methods for diagnosis, the investigation concerning the cellular and molecular mechanisms involved in the pathobiology of this complication is scarce. Prior studies have proposed altered intrinsic and extrinsic innervations of the lower gastrointestinal tract, as main responsible for the disturbances in motility, sensation, secretion, and absorption (He et al., ; Yoneda et al., ; Furlan et al., ; Honoré et al., ). However, deeper biochemical and histomorphological changes seem to occur in the gastrointestinal tract with the progress of disease (Sánchez et al., ; Zhao et al., ; Dorfman et al., ). In this regard, impaired function of intestinal barrier was observed in type 1 diabetes patients and in animal models (Zanoni and Fernandes Pereira, ). Several reports have shown that
Cell Biology International – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
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