Abstract— Fluoxetine (10 mg kg−1, i.p.) caused a three‐ to fourfold increase in extracellular 5‐hydroxytryptamine (5‐HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition of l‐5‐hydroxytryptophan at 20 or 40 mg kg−1, i.p. doses, magnified the increase in extracellular 5‐HT to as much as 16 times basal levels, although these doses of l‐5‐hydroxytryptophan alone had only small effects on extracellular 5‐HT. The increased formation of 5‐HT following l‐5‐hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5‐HT caused by uptake inhibition.
Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science – Wiley
Published: Aug 1, 1993
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