Extracellular 5‐hydroxytryptamine concentration in rat hypothalamus after administration of fluoxetine plus l‐5‐hydroxytryptophan

Extracellular 5‐hydroxytryptamine concentration in rat hypothalamus after administration of... Abstract— Fluoxetine (10 mg kg−1, i.p.) caused a three‐ to fourfold increase in extracellular 5‐hydroxytryptamine (5‐HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition of l‐5‐hydroxytryptophan at 20 or 40 mg kg−1, i.p. doses, magnified the increase in extracellular 5‐HT to as much as 16 times basal levels, although these doses of l‐5‐hydroxytryptophan alone had only small effects on extracellular 5‐HT. The increased formation of 5‐HT following l‐5‐hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5‐HT caused by uptake inhibition. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science Wiley

Extracellular 5‐hydroxytryptamine concentration in rat hypothalamus after administration of fluoxetine plus l‐5‐hydroxytryptophan

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Publisher
Wiley
Copyright
1993 Royal Pharmaceutical Society of Great Britain
ISSN
0022-3573
eISSN
2042-7158
D.O.I.
10.1111/j.2042-7158.1993.tb07105.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— Fluoxetine (10 mg kg−1, i.p.) caused a three‐ to fourfold increase in extracellular 5‐hydroxytryptamine (5‐HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition of l‐5‐hydroxytryptophan at 20 or 40 mg kg−1, i.p. doses, magnified the increase in extracellular 5‐HT to as much as 16 times basal levels, although these doses of l‐5‐hydroxytryptophan alone had only small effects on extracellular 5‐HT. The increased formation of 5‐HT following l‐5‐hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5‐HT caused by uptake inhibition.

Journal

Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical ScienceWiley

Published: Aug 1, 1993

References

  • DL‐5‐Hydroxytryptophan‐induced changes in central monoamine neurons after peripheral decarboxylase inhibition
    Fuxe, Fuxe; Butcher, Butcher; Engel, Engel
  • Effects of Lilly 110140, a specific inhibitor of 5‐hydroxytryptamine uptake, on food intake and on 5‐hydroxytryptophan‐induced anorexia
    Goudie, Goudie; Thornton, Thornton; Wheeler, Wheeler
  • Structure and function of the brain serotonin system
    Jacobs, Jacobs; Azmitia, Azmitia
  • Effects of serotonin‐mimetic drugs on mouse‐killing behavior
    Molina, Molina; Gobaille, Gobaille; Mandel, Mandel
  • Serotonin uptake blockers inhibit the firing of presumed serotonergic dorsal raphe neurons in vitro
    Rigdon, Rigdon; Wang, Wang

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